The research and development of the Image Toolbox was completed by Elliot R. McVeigh, Ph.D., Fady Dawoud, Ph.D., Amir Pourmorteza, Ph.D., Karl H. Schuleri, M.D., and Albert C. Lardo, Ph.D., all of the Johns Hopkins University School of Medicine at the time the invention was made.
The SQuEEZ technology is based on the ability to track the heart wall as it moves during the contraction of the heart to allow quantitative assessment of regional heart wall motion from cardiac CT data. The analysis can accurately quantify the regional heart wall motion of the left ventricle. SQuEEZ functional analysis is an essential component of the Image Toolbox.
SQuEEZ is used with three other cardiac image measurements in the Image Toolbox to determine which heart failure patients may benefit from Cardiac Resynchronization Therapy (CRT). CRT is used by cardiologists to maintain the rhythm of the heart in patients with damage to the heart muscle; however, 30% to 40% of patients who have the devices implanted do not benefit from the therapy. The Image Toolbox can accurately determine the best possible location for implantation of the electrical leads for the CRT device and has improved the effectiveness of CRT implantation in an early clinical study.
“We are very pleased that Johns Hopkins Technology Ventures has licensed this capability to CardioWise. The pioneering efforts of the inventors over the past few years to develop the method that has resulted in the Image Toolbox and SQuEEZ have brought extremely important new quantitative information to evaluate and treat patients with cardiovascular disease and heart failure,” said Jack Coats, CEO of CardioWise, Inc. We are excited about the possibility of helping many heart failure patients to receive CRT implants by making them more effective in improving patients’ quality of life.”