Clinical Use of the LARIAT® with EpiRAIL™ Procedure for Left Atrial Appendage Exclusion

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New Research Shows Nearly Half of Elderly Suffer Decreased Mobility During Lockdown

In a survey of UK adults with parents over the age of 75, while over half (52%) of respondents remain worried about their parents catching Covid, 48 percent are concerned about parental loneliness, and 46 percent about their parents falling alone and not being able to get up or get help. This figure remained high even among those whose parents are in care homes, with 37% of respondents still most concerned about parents falling over.

American College of Cardiology Names Ravee Kurian COO/CFO

Kurian comes to ACC following a 20-year stint at Publicis Sapient, a leading technology and communications consultancy, where he led critical and sensitive digital transformation initiatives for Fortune 500 and U.S. federal clients.

SentreHEART, Inc., announced it has successfully completed nine First-In-Human procedures utilizing the LARIAT® with EpiRAIL™ at John Paul II hospital in Krakow, Poland. The LARIAT with EpiRAIL is an epicardial-only, percutaneous approach to complete and permanent closure of the left atrial appendage (LAA) in patients with atrial fibrillation and increased risk of stroke. All cases were performed by Dr. Kryzstof Bartus of John Paul II Hospital and Dr. Randy Lee of UCSF. The EpiRAIL received CE mark clearance and will undergo continued evaluation at European centers.

The LARIAT is differentiated from all other percutaneous LAA closure devices in Europe being the only non-implant solution for complete and permanent exclusion of the LAA. Using a non-surgical, image guided approach, the LARIAT with EpiRAIL enables clinicians to precisely deliver a pre-tied suture loop to the base of the LAA from the outside that leaves no metal or foreign material inside of the heart. Over time, the LAA will disappear and no longer be a source for blood clots in patients with atrial fibrillation. The LARIAT with EpiRAIL eliminates the requirement of a transseptal catheterization in order to enter the left atrium of the heart. Instead, a single access approach is utilized to deliver the LARIAT using the innovative EpiRAIL vacuum stabilization system.

“The LARIAT with EpiRAIL is a true game changer in the area of percutaneous LAA closure,” stated Dr. Bartus. “The benefits we have seen in this early experience is the elimination of transseptal catheterization, no manipulation within the heart that may lead to thrombus formation, and no use of contrast in the heart which will be a benefit to patients with renal disease.”

Patients with atrial fibrillation (AFib) are five times more likely to suffer a stroke than those with normal sinus rhythm1. The LAA is recognized as the primary source of stroke-causing blood clots originating from the heart in patients with non-valvular atrial fibrillation2. By closing the LAA, it is believed the incidence of stroke may be reduced thus eliminating the requirement for life-long anticoagulation.

“The initial experience with the EpiRAIL approach with the LARIAT device for percutaneous LAA closure has been outstanding and is a revolutionary advancement. Epicardial visualization of the LAA via the EpiRail approach allows for the LARIAT snare to easily be passed over the LAA resulting in a faster and safer LAA closure procedure,” says Dr. Lee.

SentreHEART, the manufacturer of the LARIAT® Suture Delivery Device, is presently conducting the prospective, multi-center, randomized controlled Trial known as the aMAZE Trial ( in up to 65 centers within the United States. The Trial is a superiority design and intends to demonstrate the LARIAT procedure for LAA closure, when used in adjunct with subsequent Pulmonary Vein Isolation (PVI) catheter ablation, will lead to a reduced incidence of recurrent AFib compared to PVI alone in those patients that suffer from drug-refractory, persistent and long-standing persistent AFib.

Unlike LAA implant solutions for AFib, the aMAZE Trial seeks to potentially treat an underlying disorder of AFib by mechanically and electrically isolating the base of the LAA in a single step using the percutaneous, non-implant LARIAT suture delivery device.

Studies have demonstrated the LARIAT not only closes the LAA mechanically3 but may also isolate electrical activity4 within the LAA. Having a non-implant option that may both electrically and mechanically isolate the LAA is a potentially important addition to the treatment armamentarium for clinicians treating patients with persistent or longstanding persistent AFib.

Learn more about the aMAZE Trial, including patient eligibility here.



Dr Jonathan Slotkin Appointed to Peer Well Board of Directors

Alongside the appointment, PeerWell is launching its new clinical practice, PeerWell Health.

Zimmer Biomet Announces New Appointments to Executive Leadership Team

Wilfred van Zuilen Appointed as President of Europe, Middle East and Africa. Nitin Goyal, M.D. Appointed to Newly Created Role of Chief Science, Technology and Innovation Officer.

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