Pivotal Data From REPRISE III and EWOLUTION Among Four Late-breaking Clinical Trials to be Presented at EuroPCR 2017

Sunday, July 5, 2020

All events are listed in Central European Summer Time (CEST) and take place at the Palais des Congrès. For additional details about Boston Scientific data presentations and sponsored symposia, go to www.bostonscientific.com/EuroPCR2017 or visit the Boston Scientific booth located on Level 1, Hall Passy F21.

The company will also host an investor event and webcast on Tuesday, May 16, from 16:00 to 17:00 (CEST)/ 10:00 to 11:00 AM (EDT) to discuss its interventional cardiology and structural heart portfolios. The live webcast and replay will be accessible at www.bostonscientific.com/investors with the latter becoming available approximately one hour following the completion of the event.

Boston Scientific (NYSE: BSX) today announced the schedule of key data presentations, including four late-breaking clinical trials, that will be featured at the annual EuroPCR Scientific Program, in Paris, on May 16-19. The late-breaking clinical trials include the following:

  • Evaluation of 30-day safety and one-year efficacy outcomes from the REPRISE III trial, a prospective, randomised investigation of the LOTUS™ Valve System*, a transcatheter aortic valve implantation (TAVI) device against the CoreValve® TAVI System (Medtronic).
  • The LOTUS Valve RESPOND study providing one-year, ‘real-world’ clinical and device performance outcomes data.
  • Three-year outcomes of the EVOLVE II trial assessing the SYNERGY™ Bioabsorbable Polymer Drug-Eluting Stent System in patients with diabetes.
  • Data from the EWOLUTION registry, a prospective multicenter study of ‘real-world’ outcomes with the WATCHMAN™ Left Atrial Appendage Closure (LAAC) Device.

Ian Meredith, M.D., executive vice president and global chief medical officer, Boston Scientific notes, “This year’s EuroPCR congress will provide us the opportunity to share the performance of our LOTUS Valve platform in the REPRISE III trial,which is the first large, global, randomized head-to-head trial of two contemporary TAVI valves, as well as findings from the RESPOND and RESPOND Extension studies.”  He went on to say, “These data, along with findings from the European registry for the WATCHMAN device, further demonstrate  the value our minimally-invasive structural heart therapies bring to physicians in their pursuit of delivering the highest quality care to their patients.”


Tuesday, May 16

  • The LOTUS Valve System: A prospective, randomised investigation of a novel TAVI system: the REPRISE III trial: Ted E. Feldman, M.D., will present at 12:30 in the Main Arena.
  • The LOTUS Valve System: The RESPOND study at one-year: primary endpoint outcomes with a repositionable and fully retrievable aortic valve in routine clinical practice: Nicolas Van Mieghem, M.D., Ph.D., will present at 16:03 in the Maillot room.

Wednesday, May 17

  • SYNERGY Stent: Outcomes after PCI with a bioabsorbable polymer-coated, everolimus-eluting coronary stent in patients with diabetes: three-year results from the EVOLVE II diabetes substudy: Martine Gilard, M.D., will present at 11:35 in the Maillot room.

Thursday, May 18

  • The LOTUS Valve System: Thirty-day outcomes in patients treated with a repositionable and fully retrievable aortic valve designed to reduce the incidence of conduction disturbances (RESPOND Extension Study): Daniel Blackman, M.D., will present at 8:30 in room 342B.
  • WATCHMAN LAAC Device: Real world net benefit of LAA closure at one year: safety and efficacy results in the EWOLUTION all-comers study: Martin W. Bergmann, M.D., will present at 11:47 in the Maillot room.
  • Agent™ Paclitaxel-Coated Balloon Catheter**: Drug-coated Balloons for the treatment of coronary in-stent restenosis: a randomised, multicentre, controlled clinical study: Christian W. Hamm, Ph.D., will present at 14:45 in room 342B.


*The LOTUS™ valve system is currently not available for use or sale.
**In the U.S., the Agent™ Paclitaxel-Coated balloon catheter is investigational and not available for sale.

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