Zoll Medical reports the VEST Trial studied the use of the LifeVest WCD for patients who had recently suffered a heart attack (clinically known as a myocardial infarction or “MI”) and had a reduced heart function (defined as a low-ejection fraction or “EF” of 35 percent or less). The trial enrolled 2,300 low-EF, post-MI patients, with or without revascularization (such as a stent placement or bypass procedure), age 18 or older across more than 100 trial sites in four countries. Patients were randomized to receive the LifeVest WCD with medications or medications alone for 90 days to determine the potential mortality benefit of the LifeVest WCD.

The VEST Trial results will be presented and discussed during the following sessions:

  • A Late-Breaking Clinical Trial presentation titled, “Efficacy of a Wearable Cardioverter-Defibrillator after Myocardial Infarction: Results of the Vest Prevention of Early Sudden Death Trial (VEST)” by Dr. Olgin on Saturday, March 10, 2018 during the 9 a.m. – 10 a.m. ET session in the Main Tent, Hall C.
  • A press conference for registered media will immediately follow the Late-Breaking Clinical Trials session at 10:15 a.m. – 11:15 a.m. ET on March 10 in room #224 ABC.
  • A presentation titled, “Protecting Patients at Risk of Sudden Cardiac Death: Results of the Vest Prevention of Early Sudden Death (VEST) Trial” by Dr. Olgin on Monday, March 12, 2018 at 11:30 a.m. – 12:30 p.m. ET in Industry-Expert Theater 1, Expo Hall, #704.

The LifeVest WCD is prescribed for patients at risk of sudden cardiac death (SCD), including patients with a low-EF who have recently suffered a heart attack or have a new diagnosis of heart failure. Ejection fraction, a measure of the heart’s pumping ability, is the most powerful predictor of long-term mortality.1 Numerous clinical studies demonstrate the risk of mortality in low-EF patients is highest in the first 90 days for following a cardiac event, such as a heart attack or a new diagnosis of heart failure, including high mortality from SCD.1,2,3,4,5,6

The LifeVest WCD continuously monitors the patient’s heart and, if a life-threatening heart rhythm is detected, the device delivers a treatment shock to restore normal heart rhythm. LifeVest gives physicians time to optimize medical therapy and assess a patient’s long-term risk for sudden death. LifeVest allows patients to return to their common activities of daily living, while having the peace of mind they are protected from SCD.

The 2017 American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Rhythm Society (HRS) Guideline for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death includes recommended use of the WCD for a wide range of patients at risk of SCD, including those who have a low-EF following a heart attack or a new diagnosis of heart failure.

LifeVest will be showcased in Booth 1801 in the West Concourse, along with additional products from ZOLL including the ZOLL R Series® Monitor Defibrillator, AutoPulse® Resuscitation System, and the Hospital Wearable Defibrillator.


Halkin A et al. Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction: CADILLAC risk score. J Am Coll Cardiol. 2005;45:1397–1405.
2Solomon SD et al. Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both. NEJM. 2005;352:2581–2588.
3Adabag AS et al. Sudden death after myocardial infarction. JAMA. 2008;300(17):2022–2029.
4Zishiri ET et al. Early risk of mortality after coronary artery revascularization in patients with left ventricular dysfunction and potential role of the wearable cardioverter defibrillator. Circ Arrhythm Electrophysiol. 2013;6:117–128.
5Weintraub W et al. Prediction of long-term mortality after percutaneous coronary intervention in older adults: Results from the National Cardiovascular Data Registry. Circulation. 2012;125:1501–1510.
6Packer M et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. NEJM. 1996;334(21):1349–1355.
7Kutyifa V et al. Use of the wearable cardioverter defibrillator in high-risk cardiac patients: Data from the prospective registry of patients using the wearable cardioverter defibrillator (WEARIT-II Registry). Circulation. 2015;132(17):1613–1619.