ZipLine Medical, Inc. today announced publication of results from two groundbreaking clinical studies, further demonstrating both clinical and economic benefits of the Zip® Surgical Skin Closure device. A peer-reviewed prospective study published in the journal Cureus revealed that incisions closed with the Zip Surgical Skin Closure had significantly lower bacterial penetration and fewer symptoms associated with surgical site infection (SSI) than sutures. Zip incisions also showed a lack of inflammation compared to sutured incisions.1

“This study confirms what our customers have been telling us anecdotally for years,” stated Amir Belson, MD, founder and Chief Technology Officer for ZipLine Medical, Inc. “In addition, the lack of inflammation may indicate that formation of scar tissue would be less with the Zip than with sutures.”

Separately, a 175-patient, investigator-sponsored study conducted at the University of Missouri comparing the Zip Surgical Skin Closure to sutures for pacemaker implant procedures was published in the Journal of Interventional Cardiac Electrophysiology. According to the authors, the Zip device delivered a reduction in pocket closure time of 26 percent and a reduction in overall procedure time of 22 percent, with no complications in the Zip cohort.2


1. Safa B, Belson A., Meschter C, et al. (August 04, 2018) In Vivo Efficacy Study Showing Comparative Advantage of Bacterial Infection Prevention with Zip-type Skin Closure Device vs. Subcuticular Sutures. Cureus 10(8):e3102. DOI 10.759/cureus.3102
2. S.M. Koerber, T. Loethen, et al. Noninvasive tissue adhesive for cardiac implantable electronic device pocket closure: the TAPE pilot study. J Interv Card Electrophysiol Published online October 15, 2018