Open Stent Solution Closes €2.5M Seed Financing Round

Open Stent Solution (OSS), a medtech start-up company developing the first open-stent heart valves, today announced the closing of a €2.5 million Seed financing round. The funding will support the development of its ribbon-shaped stented mitral valve for transcatheter replacement.

OSS’ breakthrough device is the first-ever open-stent heart valve and the only device bearing the promise to implant large size mitral valves through small delivery systems, comparable in size to best-in-class TAVI (transcatheter aortic valve implantation). The OSS valve components are attached to a ribbon-shaped open stent, which drastically reduces the overall device’s size when loaded onto a delivery system, compared to conventional, radially expanding devices.

Once implanted, the OSS heart valve gets locked, forming a perfect circular shape, with stable radial anchoring force exactly like balloon expandable devices. OSS’ ribbon-shaped open stents have an unprecedented approach compared to existing stented heart valves, which are all cylinder-shaped and radially expanding.

“We are grateful to our investors for their trust and for their support to our venture. The financing enables us to proceed to concept freeze for our unique minimally invasive solution,” said Doctor Doron Carmi, senior cardiac surgeon, founder and CEO of Open Stent Solution. “In few years from now, we aim to offer an effective transfemoral solution to millions of patients with failed mitral valves who cannot access treatment today.”

There are currently no devices approved for transfemoral or transeptal transcatheter mitral valve replacement (TMVR). Today, most patients with severe mitral regurgitation are unsuitable for open-heart surgery and cannot have their valves replaced.

The OSS funding round was led by Angels Santé, a French health business angel network, BeAngels, a Belgian business angel network, Bpifrance, the French government agency, and private investors, of which several cardiologists and cardiac surgeons.

“We have been impressed by OSS’s technology paradigm shift, which overrides radial expansion, whilst several start-up companies are currently trying to address TMVR challenges through more standard approaches,” stated Edouard Caram of Angels Santé. “As mitral regurgitation is continuing to grow as a result of an ageing global population, TMVR is expected to become one of the most prominent cardiovascular solutions of the next decade.”

TMVR challenge and need

Mitral regurgitation (MR) is the most common valvular heart disease. Mitral valve regurgitation is often the result of heart failure, myocardial infarction or other cardiomyopathies (secondary) and it is generally associated with poor clinical outcomes. [1]

“The lack of a TMVR treatment is a serious concern when we look at patients with secondary mitral valve regurgitation, as it is unfortunately associated with higher morbidity and mortality rates,” stated Thomas Modine, cardiac surgeon Hôpital Pont L’eveque – Bordeaux, France. “A transcatheter solution is very much needed and OSS’s unique approach seems to potentially address the specific anatomical challenges of the mitral space, such as sizing, due to a dilated ventricle, and the need of a flexible device.”

 

Medical Device News Magazinehttps://infomeddnews.com
Medical Device News Magazine provides breaking medical device / biotechnology news. Our subscribers include medical specialists, device industry executives, investors, and other allied health professionals, as well as patients who are interested in researching various medical devices. We hope you find value in our easy-to-read publication and its overall objectives! Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

More News!

Noze states the grant will fund a groundbreaking clinical study aimed at detecting TB in high-burden countries, using the company's DiagNoze® — a handheld breathalyzer designed for the real-time detection and screening of various medical conditions, including infectious diseases such as TB.
Research teams led by a faculty member in Purdue University’s College of Engineering will use two grants from the National Eye Institute totaling $6.7 million to further develop specialized smart soft contact lenses that continuously monitor or treat chronic ocular diseases like glaucoma, corneal neovascularization and dry eye syndromes.
The series B funding round saw participation from venture capital firms Blume Ventures, Steadview Capital, Nexus Venture Partners, Alpha Wave and Zomato founder Deepinder Goyal. Ultrahuman will deploy the funds towards building further manufacturing capacity and deeper research in the health tracking space notes Ultrahuman.
Bone Health Technologies Bone Health Technologies (BHT), a health technology innovator developing breakthrough non-invasive solutions for bone health, today announced the company has raised a...
Howard Robin, President and Chief Executive Officer of Nektar Therapeutics: "We are pleased to bring on TCGX as a new high-quality, long-term investor in Nektar as we advance rezpegaldesleukin through our Phase 2b studies in atopic dermatitis and alopecia areata. We are on track to report topline data from these studies in the first half of 2025, which will represent significant inflection points for Nektar. Today's financing further bolsters our financial position and extends the company's cash runway well into the third quarter of 2026."

By using this website you agree to accept Medical Device News Magazine Privacy Policy

Exit mobile version