Patient Enrollment is Complete in the DOD-Funded Study of Extracorporeal Hemopurification of Critically Ill COVID-19 Patients

Multicenter Effort Led by the US Department of Defense Survival Improved Significantly Among Patients Treated with Seraph 100

PURIFY OBS, an observational study of critically-ill COVID patients treated with the Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100), has recently completed enrollment.

A multicenter effort led by the US Department of Defense (DOD) published interim results in April 2021. Observations included dramatic improvement in survival and reduction in median ICU length of stay for patients treated with the Seraph 100 vs controls.

Another interim analysis from the ‘COSA Registry,’ a multicenter European study of COVID-19 patients treated with the Seraph 100 Microbind Affinity filter, also yielded positive results: Patients treated with the Seraph 100 early in their ICU stay had higher survival rates than patients treated later in their ICU stay.

“We expect the first peer-reviewed PURIFY-OBS clinical trial publication soon, now that the study has concluded. We are pleased to see these consistent and very positive results and we’re pleased to know we have helped save the lives of many critically-ill COVID-19 patients,” said ExThera Medical CEO Robert Ward. “Having treated more than 800 patients with Seraph 100 in the US alone, we have increased confidence in its safety and ability to improve outcomes for critically ill patients with COVID 19 and other serious bloodstream infections.”

The PURIFY RCT (a multicenter randomized controlled trial studying blood purification for the treatment of pathogen associated shock) has been initiated and is expected to begin enrollment in early 2022. Multicenter RCT trials are rare in the field of extracorporeal therapy and require robust signals of efficacy. It is expected that the positive clinical results observed in PURIFY OBS will continue during PURIFY RCT.

Physicians across the country are using ExThera Medical’s Seraph 100 under Emergency Use Authorization from the U.S. Food and Drug Administration to treat COVID-19 patients admitted to the ICU with confirmed or imminent respiratory failure. In 2019, the Seraph 100 was granted CE mark in the European Union for the reduction of bloodstream pathogens.

The complete PURIFY observational study is expected to be published during Q1 2022.

Medical Device News Magazinehttps://infomeddnews.com
Medical Device News Magazine provides breaking medical device / biotechnology news. Our subscribers include medical specialists, device industry executives, investors, and other allied health professionals, as well as patients who are interested in researching various medical devices. We hope you find value in our easy-to-read publication and its overall objectives! Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

More News!

The Evolut ™ FX+ TAVR system leverages market-leading valve performance with addition of larger windows to facilitate coronary access
The study was an analysis of AstraZeneca’s Phase 2 52-Week clinical trial of tralokinumab in patients with Idiopathic Pulmonary Fibrosis (IPF). The patient data from the trial was processed with Brainomix’s e-Lung tool. The tool is uniquely powered by the weighted reticulovascular score (WRVS), a novel biomarker that incorporates reticular opacities and vascular structures of the lung.
“Since the algorithm for matching patients with donors is changing across for all organs, this was a prime time to better understand whether transplant team decisions to accept a donated organ varied by patient race and gender,” she said. “We wanted to understand how the process of receiving a transplant after listing varied by race and gender, and the combination of the two, so that steps can be taken to make that process more equitable," said Khadijah Breathett, MD.
The Mount Sinai study found that primary care physicians’ approach reflects a dearth of evidence-based guidance for lung cancer screening shared decision-making in patients with complex comorbidities
This is the first ever transplantation of a genetically engineered porcine kidney into a living human recipient.

By using this website you agree to accept Medical Device News Magazine Privacy Policy

Exit mobile version