Dr. Matthieu Jeanne, Ph.D., Chief of Anesthesia and Intensive Care, Burn Treatment Center, principal investigator of the prospective randomized clinical validation study said, "This world first is an important step forward for the practice of anesthesia in general. This closed loop is the best companion for the surgeon, the anesthetist, and the patient since all three can be assured that the operation will be carried out in the best conditions of patient comfort and pain control".