"Over the past few years, our research has continued to validate the pathogenic role of SGK-1 in rare arrhythmias. We now have the first in human evidence of the benefits of targeting this activated kinase to reduce prolonged QTc," commented Philip Sager, MD, Chief Medical Officer of Thryv Therapeutics. "With this initial safety and efficacy data in hand, clinical testing can commence in people with Congenital Long QT Syndrome Types 2 and 3, where chronic and substantial QTc prolongation can lead to lethal ventricular arrhythmias."