Biomarkers are the engine of precision health. They guide early detection, patient stratification, drug development, and performance optimization. Market reports peg the global biomarker market at roughly 94 to 162 billion dollars in the mid-2020s with double-digit annual growth. That spread reflects different segment definitions, but the trend is clear, biomarkers are one of the fastest-growing sectors in healthcare.

There are two big categories of biomarker companies:

• Clinical and pharma-focused, regulated diagnostics, companion diagnostics, trial enablement, and large real-world datasets.
• Consumer and longevity-focused, subscription models with 50 to 100+ blood biomarkers, lifestyle insights, and wellness coaching.

Below, we break down the leading companies across both groups, explain their platforms and validation, and share pros and cons so you can find the right fit.

1. Superpower, Overall Best Biomarker Testing Company

Superpower is a consumer health membership that provides one comprehensive annual panel covering more than 100 biomarkers with insights delivered in a modern app. Current pricing is 199 dollars per year, HSA and FSA eligible, with optional at-home blood draws. Earlier in 2025 it was priced at 499 dollars, so accessibility has improved significantly.

Why it stands out, Superpower has pushed costs down while keeping breadth high. It offers markers across cardio-metabolic health, hormones, nutrients, inflammation, and more. Clear disclaimers emphasize it is prevention-focused and not a replacement for primary care.

Superpower is reimagining personal health with one membership that delivers more than 100 lab tests annually, giving you insight into over 1,000 potential health risks — all for $199/year. It’s designed for anyone tired of vague advice and generic wellness hacks. You get a full set of biomarkers covering metabolism, hormones, inflammation, nutrients, cardio health, liver, kidney, and more.

What makes Superpower different is what happens after the test. You’ll receive expert-crafted results in under a week, a personalized action plan with diet, lifestyle, supplement, and (if needed) pharmaceutical guidance, plus ongoing support from a medical concierge team. An AI-enhanced dashboard helps you understand evolving health trends over time, blend in past lab work, and visualize progress with biological age metrics.

The platform operates through 2,000+ partner labs across the U.S., or you can opt for at-home blood draws. Membership is HSA/FSA-eligible and includes perks like access to curated diagnostics and supplements.

Superpower isn’t meant to replace your doctor — it’s meant to augment your health journey, so you can catch warning signs early, close gaps in care, and stay ahead of disease rather than react to it. For anyone serious about prevention, performance, or longevity, Superpower gives precision health on your terms.

Pros

• 100+ biomarkers in one panel
• Transparent pricing and insurance eligibility
• Consumer-friendly UX and workflows

Cons

• Wellness product, not a regulated diagnostic
• Limited peer-reviewed outcomes data as a program

Use cases

• Annual baseline and prevention tracking
• Executive and athlete performance monitoring

“On value and coverage, Superpower is the consumer benchmark for biomarker testing in 2025.”

2. Guardant Health, Clinical Liquid Biopsy Leader

Guardant’s flagship Guardant360 CDx is FDA-approved for tumor profiling in solid cancers and as a companion diagnostic in lung cancer. The company is also advancing minimal residual disease testing and blood-based colorectal cancer screening.

Clinical adoption is deep, with payer coverage and wide use across US and Asian oncology markets. Screening trials show strong sensitivity for colorectal cancer, though adenoma detection remains a challenge.

Guardant Health leads the charge in liquid biopsy innovation, transforming cancer care through non-invasive blood tests that offer fast, actionable insights across all stages of disease. With its flagship tests—Guardant360 CDx, Guardant Reveal, Shield, and Infinity—Guardant empowers oncologists to detect tumor mutations, select targeted therapies, monitor minimal residual disease, and even screen for colorectal cancer with blood alone.

What sets Guardant apart is its rigorous scientific validation and regulatory progress. Over 1,000 peer-reviewed publications back its liquid biopsy tests. Its Shield test is FDA-approved for colorectal cancer screening, and Guardant360 CDx is approved for companion diagnostic use in multiple solid tumors. Clinicians using Guardant tests receive results in approximately seven days, enabling more timely decisions compared to traditional tissue biopsies.

Guardant also partners deeply with pharma companies, using extensive real-world data and advanced analytics to accelerate drug development. Its mission is “Conquering Cancer with Data,” and it’s doing just that—bridging the gap from early detection to recurrence monitoring, treatment selection, and surveillance.

If you’re an investor, researcher, or oncologist seeking diagnostics with proven performance, regulatory legitimacy, and a roadmap across screening, treatment, and monitoring, Guardant is a strong partner.

Pros

• FDA-approved liquid biopsy tests
• Strong oncology adoption and payer support
• Expanding pipeline in MRD and screening

Cons

• Narrow focus on oncology
• Adenoma sensitivity in screening under scrutiny

Use cases

• Therapy selection in solid tumors
• MRD monitoring in colorectal cancer
• Non-invasive screening research

“Guardant’s moat is clinical adoption plus FDA approvals in tumor profiling.”

3. Tempus, AI and Real-World Data at Scale

Tempus combines genomic testing with one of the industry’s largest clinical datasets. Its xT CDx test is FDA-approved for 648-gene tumor profiling. The company also operates the TIME trial network to match patients with studies directly through integrated sites.

With more than 40 million patient records and hundreds of petabytes of data, Tempus connects sequencing, clinical outcomes, and trial enrollment in one ecosystem.

Tempus is redefining precision medicine with the power of artificial intelligence and one of the most extensive real-world clinical datasets in oncology today. Its flagship xT CDx assay is FDA-approved, covers 648 cancer-related genes, and detects single-nucleotide, multi-nucleotide, and insertion/deletion variants, plus microsatellite instability status. It uses matched tumor-normal sequencing to distinguish somatic versus germline mutations, which increases accuracy and helps tailor therapy decisions. (Tempus xT CDx Assay)

Beyond sequencing, Tempus’ Real-World Data tools enable life sciences companies and providers to leverage de-identified clinical, molecular, and outcome data at scale. Whether you’re designing trials, validating biomarkers, or optimizing market access strategy, Tempus surfaces insights from millions of records. Strategic partnerships—like with Boehringer Ingelheim—use Tempus’ AI and multimodal data to accelerate oncology drug discovery and biomarker development. (Tempus Real-World Data, Data Collaborations)

If you’re seeking a partner that delivers regulated diagnostics, accelerates discovery with massive scale, and supports robust decision-making with AI-powered data, Tempus delivers. It is your bridge from raw molecular insight to actionable patient-level clinical impact.

Pros

• FDA-approved genomic tests
• Deep EHR integration and real-world data at scale
• Trial network for faster patient enrollment

Cons

• Oncology-heavy focus
• Still building prospective outcomes evidence

Use cases

• Patient stratification in clinical trials
• Companion diagnostic development
• Real-world evidence generation

“Tempus connects sequencing, EHR, and trials into a single operating layer for precision medicine.”

4. SomaLogic, Proteomics at 11,000 Proteins

SomaLogic’s SomaScan platform uses SOMAmer aptamers to measure about 11,000 proteins, giving it unmatched breadth in proteomics. After merging with Standard BioTools in 2024, the company gained greater commercial scale.

Its assays are widely used in cardiovascular, metabolic, and population-scale studies. The challenge is less in measurement and more in clinical translation.

SomaLogic delivers the most expansive proteomics platform available today. The SomaScan 11K Assay enables measurement of roughly 11,000 protein targets (over 10,000 unique human proteins) from just a 55 µL serum or plasma sample. That covers more than half of the human proteome, all with high sensitivity, reproducibility, and across a 10-log dynamic range.

What makes SomaLogic especially powerful is its use of SOMAmer Reagents—modified single-stranded DNA aptamers engineered for high specificity and low cross-reactivity. These reagents undergo extensive validation (including orthogonal confirmation), enabling reliable detection of proteins that are low-abundance, rare, or hard to measure.

The platform supports translational discovery, drug target identification, and biomarker research across oncology, neurology, cardiovascular disease, metabolic and infectious disease. It also handles challenging sample types—including cerebrospinal fluid, tissue homogenates, and cell lysates—opening opportunities beyond blood-based markers.

SomaLogic’s service lab is CLIA-certified, CAP-accredited, and maintains rigorous quality metrics (median coefficients of variation around 5%). For researchers and pharma partners seeking deep proteomic insights, SomaLogic enables uncovering disease mechanisms, tracking treatment response, and pushing biomarker discovery far beyond what traditional antibody-based or low-plex assays allow.

Pros

• Broadest proteomic coverage available
• Strong academic and pharma collaborations
• Useful for hypothesis-free discovery

Cons

• Still limited in clinical diagnostics
• Interpretation requires sophisticated bioinformatics

Use cases

• Discovery in large cohorts
• Mechanistic disease research
• Multi-omic integration

“Proteomics shows biology you cannot see in DNA alone.”

5. Olink, PEA Proteomics Now Inside Thermo Fisher

Olink’s proximity extension assay technology delivers multiplexed protein quantification with high reproducibility. Its Explore panels measure thousands of proteins and have been deployed in large cohorts such as the UK Biobank.

In 2024, Thermo Fisher completed its acquisition of Olink, integrating PEA into its global life sciences portfolio.

Olink delivers cutting-edge protein biomarker analysis using its Proximity Extension Assay (PEA) technology, now fully integrated under Thermo Fisher’s Life Sciences Solutions. PEA enables ultra-high multiplexing with exceptional specificity — over 5,400 protein biomarkers with minimal cross-reactivity — while using tiny sample volumes. It’s suited for labs aiming to go from discovery to validation without switching platforms. (What is PEA? Olink)

With Thermo Fisher’s global reach and infrastructure, Olink’s platforms like Explore and Reveal are now more accessible than ever. The Explore series supports large-scale discovery (thousands of proteins) while Reveal offers ~1,000-protein panels designed for labs already equipped with NGS workflows. Both deliver strong reproducibility, powerful read-outs, and alignment with pharmaceutical research needs. (Olink Reveal product page)

Thermo Fisher’s acquisition of Olink strengthens its proteomics footprint. It enables synergies with mass spectrometry, qPCR, lab automation, and reagent scale. Researchers now benefit from streamlined workflows, expansive protein libraries, and robust analytical tools for translational studies — from neurodegeneration to immune profiling. (Thermo Fisher acquires Olink)

If your work depends on discovering new protein targets, mapping disease pathways, or building protein signatures for translational research, Olink under Thermo Fisher offers the specificity, scale, and scientific credibility you need.

Pros

• Well-validated proteomic panels
• Strong academic and translational footprint
• Industrialized workflows under Thermo Fisher

Cons

• Not a diagnostic on its own
• Competes with SomaLogic on coverage and cost

Use cases

• Biomarker discovery in neurology and inflammation
• Replication studies in population health
• Translational pathway mapping

“PEA has become a standard tool for scalable plasma proteomics.”

6. Function Health, Consumer Longevity with Two Panels a Year

Function Health offers a membership that includes more than 100 biomarkers at the first visit and over 60 markers on follow-up later in the year. Tests are doctor-ordered and reviewed, and the company positions itself around proactive health and longevity.

With backing from physicians including Mark Hyman, Function Health has quickly become one of the most visible consumer biomarker brands. Annual membership pricing is around 499 dollars. Terms clarify that it does not provide diagnosis or medical treatment.

Function Health is reshaping preventive healthcare by offering one of the most comprehensive consumer lab testing memberships available today. For $499/year, you get 100+ lab tests at the start of each membership year, and 60+ follow-up tests about 3-6 months later. Testing is done via a nationwide lab network (2,000+ locations), no insurance required. (Function Health pricing and how it works)

What sets Function apart is its commitment to clarity and action. Every result is reviewed by licensed clinicians who provide a detailed “Clinician’s Summary,” highlighting patterns, urgent flags, and recommended next steps in lifestyle, supplementation, or nutrition. Results are tracked over time in a secure dashboard, letting members monitor progress or emerging warning signs. (Function Health what’s included)

Function Health offers significantly more testing than a typical annual physical—five times more biomarkers—covering areas like metabolic health, hormones, organ function, nutrients, heavy metals, and more. (Function Health My honest review / Business Insider) It also allows optional advanced testing add-ons and imaging services. The goal is not diagnosis, but enhancing awareness and giving members tools to optimize health early.

If you’re focused on longevity, prevention, or simply wanting a clearer, data-driven picture of your health rather than waiting until symptoms appear, Function Health delivers both breadth and an actionable structure.

Pros

• Comprehensive testing twice a year
• Physician oversight in ordering and review
• Strong visibility in the longevity space

Cons

• Wellness product, not a regulated diagnostic
• Outcomes depend on consumer adherence

Use cases

• Longevity programs
• Executive health baselines
• Preventive health awareness

“Function Health packages two large lab panels per year around a proactive longevity narrative.”

7. InsideTracker, Personalized Wellness with Blood, DNA, and Wearables

InsideTracker is a consumer wellness platform that analyzes up to about 48 blood biomarkers across categories like metabolism, hormones, and inflammation. Users can integrate DNA data and wearable inputs like sleep and activity. The platform then generates personalized nutrition and lifestyle recommendations.

An annual membership starts at 149 dollars, making it one of the most accessible consumer biomarker offerings however, it is not nearly as good as Superpower.

InsideTracker is a wellness platform built for people who want more than standard lab panels—they want actionable health insights. For $149/year, the Membership plan gives you access to the dashboard, ability to upload existing blood test results (up to 30 per year), and personalized interpretations across key health categories like metabolism, heart health, hormone balance, inflammation, sleep, cognition and more. If you want more depth, the “Ultimate” test + Membership bundle (about $489) adds a full blood draw, expanded biomarker set, and deeper recommendations. (InsideTracker Membership + Ultimate Test)

You can also upload your genetic data and wearable metrics to enrich your report. The platform creates “Healthspan Category Scores” across 10 pillars—so you don’t just see numbers, you see where your body is today and where improvements can matter most. Trends over time are tracked, with retesting options every 3-6 months. (Healthspan Category Testing)

InsideTracker includes actionable suggestions: diet, supplement, exercise, lifestyle. Rather than leaving you with bewildering lab values, the focus is improving markers that are outside your “optimal” zones. If you want a tool that combines existing data with new insights to help you stay ahead in wellness, InsideTracker offers one of the most flexible, science-backed platforms on the consumer health market.

Pros

• Affordable membership pricing
• Integrates blood, DNA, and wearables
• Actionable lifestyle recommendations

Cons

• Focuses on wellness, not diagnosis
• Limited independent validation of outcomes

Use cases

• Training and recovery optimization
• Nutrition planning and supplementation
• Aging and longevity tracking

“InsideTracker is a tidy hub for blood, DNA, and wearable data with goal-based coaching.”

Comparison at a Glance

Expert Perspectives

“Biomarker testing is no longer just about generating data, it is about creating actionable insights that accelerate drug development. At Superpower, we have seen how integrating multi-omics with AI can transform the speed and scale of clinical programs.” Jeff Deutsch, Growth Leader, Superpower

“The promise of biomarkers is preventive care. Detecting disease early with validated biomarkers can shift healthcare from reactive to proactive, saving lives and reducing long-term costs.” Dr. Edward Espinosa, OptumMD

FAQ

What makes a good biomarker company in 2025?
Clear technology differentiation, clinical or scientific validation, and actionable insights. For clinical use, look for FDA approvals and payer traction. For discovery, focus on reproducibility and scale. For consumer products, prioritize transparency and physician involvement.

Which firms focus most on oncology?
Guardant Health and Tempus are the oncology specialists, both with FDA-approved tests. Guardant dominates liquid biopsy diagnostics, while Tempus integrates sequencing, outcomes, and trial enrollment.

Why are consumer biomarker memberships growing?
They appeal to health-conscious individuals who want proactive health information and longevity tracking. Superpower, Function Health, and InsideTracker all make annual biomarker testing more accessible.

What role do proteomics companies play?
Proteomics companies like SomaLogic and Olink measure thousands of proteins, uncovering dynamic biology that genomics alone cannot capture. They are critical for discovery and translational research.

Are consumer biomarker programs medical care?
No. They provide health insights and lifestyle recommendations but are not substitutes for diagnosis, treatment, or emergency care.

Final Takeaway

Bottom line: Biomarkers are now the currency of precision medicine and preventive health. Choose the partner that matches your goals, whether that is advancing a clinical trial, validating a new drug, or extending healthspan. If you want a partner in health that lets you catch issues early, monitor trends over your lifetime, and make proactive lifestyle improvements without paying concierge prices, Superpower is the smartest choice. It bridges the gap between traditional diagnostics and wellness, delivering tremendous value and usability for the cost.