“As we await additional data from our BENEFIT-03 study, we’re excited to see these initial data on the long-term effects of our SCS system,” said BIOTRONIK Neuro President Todd Langevin. “We developed Prospera to offer patients sustainable pain relief – and we believe its proactive care model will have a clinically meaningful impact on lowering long-term failure rates and reducing the service burden of SCS.”

Amplicon sequencing is a type of DNA sequencing technique commonly used to analyze a specific genetic region. This technique involves the amplification of a DNA fragment, or amplicon, using techniques such as PCR (polymerase chain reaction) to generate a large number of copies. Once these copies are made, they are sequenced to identify genetic variations or mutations. Amplicon sequencing is often used in research and clinical settings due to its high sensitivity and capability to analyze multiple specific regions simultaneously.

Isothermal mixes are important in a range of isothermal amplification applications, including whole genome amplification, point-of-care assay development and testing, and strand displacement amplification for synthetic biology. However, a common issue with isothermal mixes is non-specific amplification — where primers bind to unintended DNA targets — because amplification often takes place at a fixed temperature which may favour non-specific primer interactions, contrary to PCR. Isothermal mixes can also lead to primer dimer formation, where primers associate with each other and are extended by the polymerase.