Home Blog Page 10

New Project Will Enable Rapid Detection of Staphylococcus Bacteria & Create a New Bio-based Disinfectant to Reduce Hospital-acquired Infections

According to data from the European Centre for Disease Prevention and Control, approximately 4 million patients acquire a healthcare-associated infection (HAI) or nosocomial infection each year in the European Union and approximately 37,000 deaths are the direct result of these infections, making them a major cause of mortality. Infectious microorganisms acquired in hospitals are often resistant to many common antibiotics. By 2050, the number of deaths caused by drug-resistant infections is expected to increase to 10 million worldwide, thus posing a serious public health problem.

Early detection of nosocomial infections and effective disinfection of hospitals and healthcare centres are key to reducing these figures, but the methods currently used have their limitations. Hence the creation of the NOSOSENS Project, which is working on a new bio-based disinfectant designed to eliminate the main pathogens on a new, flexible and portable biosensor platform. It uses printed electrochemical sensors for rapid, selective detection of Staphylococcus aureus, which is resistant to methicillin and responsible for 11% of nosocomial infections.

The Fundación de Investigación Hospital General Universitario de Valencia, the Plastics Technology Centre (AIMPLAS), the companies Química Deambla-Rogemar and Crespo Printing Group, coordinated by the Assessoria de Gestió y Comunicacions (AGC), are collaborating on this research project funded by the Valencian Institute for Competitiveness and Innovation (IVACE+i) through the call for Strategic Projects in Cooperation 2023 of the Valencian Innovation Agency in conjunction with the ERDF Programme.

Immediate test and environmentally friendly disinfectant

The diagnostic method par excellence currently used in hospitals for the prevention of nosocomial diseases involves the detection of pathogens by means of cell culture microscopy on a monthly basis. The results become available in four to five days on average. The new portable electrochemical biosensor platform from NOSOSENS provides immediate specific detection and quantification of bacteria from the Staphylococcus aureus family. It will also include a monitoring, management and display system for data and alerts.

The current problem with cleaning products is that pathogens’ antimicrobial resistance makes disinfectant solutions less effective Stronger disinfectants such as peracetic acid must therefore be used, though it causes long-term damage to surfaces and cannot be included in daily cleaning protocols in healthcare facilities. The solution proposed by NOSOSENS has a high biocidal potential, but is biobased and biodegradable, making it less aggressive and more environmentally friendly.

Both innovations will be tested at Hospital General Universitario de Valencia, which will be equipped with a portable, easy-to-use early detection system for healthcare personnel to test for this type of bacteria, as well as an effective and sustainable pathogen elimination system for surgical elements and areas. Synergies with the sensorization platform will optimize disinfection processes for safety against hospital-acquired infections. This system will make it possible to trace and control the infectious agent and take rapid action to eliminate surface colonization, as necessary, thus minimizing the risks associated with hospital stays.

Pioneering Hospitals Take Major Steps Towards Decarbonizing Healthcare with Philips

Decarbonizing Healthcare with Philips

Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced significant greenhouse gas (GHG) emissions reduction results following collaboration with customers worldwide to assess and mitigate their carbon footprints, while also enhancing patient care and customer operational efficiency. Key achievements include:

  • Jackson Health System (US): A 47% projected reduction in CO2e emissions by replacing legacy patient monitors, comprising 508-tons equipment lifecycle CO2e reduction and 177 tonnes CO2e reduction due to battery and paper savings.
  • Champalimaud Foundation (Portugal): 24% emissions reduction per exam in its radiology and nuclear medicine department, with a goal to halve the carbon footprint of its diagnostic and interventional imaging departments by 2028.
  • Rennes University Hospital (France): Opportunities identified to reduce annual emissions of the cath lab through energy savings and sustainable equipment upgrades.
  • County Durham and Darlington NHS Foundation Trust (UK): A sustainability blueprint developed for the trust’s ICU, focusing on waste reduction and energy efficiency.

“Good healthcare has to be environmentally sustainable, which means words and good intentions urgently need to be turned into positive actions. Philips is committed to co-creating solutions that drive measurable, impactful change. By working with like-minded action leaders around the world, sharing with them our expertise in sustainable healthcare operations, we are helping them to take critical and tangible steps toward a greener future, while at the same time enhancing patient care,” said Robert Metzke, Global Head of Sustainability at Philips.

Examples of projects based on a comprehensive ‘360-degree’ holistic life cycle assessment (LCA) of a hospital organization’s sustainability, together with more detail about key results [1] include:

Jackson Health System (Miami, Florida, US)
Philips conducted a retrospective Life Cycle Assessment of patient monitoring at 3 of Jackson Health System’s hospitals revealing that by switching to the Philips monitoring platform from their previous provider, over a 10-year period, they may be able to reduce carbon emission from patient monitoring by 47%. Data from the LCA assessment indicated that the Philips IntelliVue and EarlyVue monitors can help reduce the health system’s patient monitoring carbon footprint by 508 tons of CO2e across all facets of the lifecycle. Battery and paper savings reduced CO2e by an additional 177.1 tons.  This significant reduction also eliminates the need for an estimated 420,000 disposable AA batteries and 6.5 million sheets of paper, which can allow the health system to save $1.2 million over a 10-year device lifetime.

Champalimaud Foundation (Lisbon, Portugal)
In March 2023, Philips and Champalimaud Foundation, a leader in translational biomedical research and clinical care, entered into a strategic partnership aimed at halving the carbon footprint of Champalimaud’s diagnostic and interventional imaging departments by 2028. Potential reductions associated with equipment replacement and usage over the 5-year period were calculated and a replacement plan put into action. Based on a comprehensive LCA, the baseline carbon footprint of the existing imaging equipment was 2,175 tonnes CO2e. The collaboration achieved a 24% reduction in CO2e emissions per exam in the first year, primarily through EcoDesign equipment replacement and incorporating circular practices.
Read the full case study here.

Rennes University Hospital (Rennes, France)
Part of a five-year technology, research, and innovation partnership, this project aimed to decarbonize and reduce the overall environmental impact of Rennes University Hospital’s catheterization laboratory (cath lab), in which a Philips Image Guided Therapy System – Azurion – is used to treat strokes and aneurysms. Conducted in accordance with the latest European Union Product Environmental Footprint guidelines, a LCA of the carbon footprint and other pollutants associated with Azurion and the consumables used during interventional procedures revealed opportunities to reduce the lab’s annual emissions through energy savings, circular upgrades, and refurbishment. The assessment also identified opportunities to reduce the rare metal content of equipment and consumables.
Read the full case study here.

County Durham and Darlington NHS Foundation Trust (Darlington, UK)
Philips partnered with County Durham and Darlington NHS Foundation Trust (CDDFT) to identify key opportunities to reduce greenhouse gas emissions and materials waste in the intensive care unit (ICU) at Darlington Memorial Hospital. Key areas highlighted by the team for enhancing sustainable ICU care included patient discharge optimization, waste reduction in the supply chain, staff training to encourage knowledge sharing and a sustainability culture, energy reduction and materials waste associated with ICU equipment, and the strategic refurbishment of buildings to reduce their emissions. The results formed a blueprint to drive further change and improvement across the Trust, in line with the UK NHS’s target of being the world’s first net zero national health service by 2040.
Read the full case study here.

Vanderbilt University Medical Center (Nashville, US)
In collaboration with leading sustainability experts at Vanderbilt University Medical Center, Philips collaborated in a LCA project to measure and mitigate emissions associated with an entire radiology department. The results revealed that 10-year emissions from Vanderbilt’s current diagnostic radiology unit amounted to 4,600 tonnes CO2e, primarily associated with lifecycle emissions from its MR imaging suite (48%) and CT imaging suite (24%). Key mitigation recommendations for radiology departments included accelerating digitization, embracing circularity, and transitioning to renewable energy sourcing. Recommendations for health technology companies included designing for energy reduction, applying circular design principles, and developing smart image storage.

Philips is driving sustainable and equitable healthcare

Philips recognizes the link between human and environmental health, with healthcare systems responsible for over 4% of global CO2 emissions [2] and significant materials usage. As part of Philips’ broader ESG commitments, Philips is driving the transition towards sustainable and equitable healthcare to deliver better care for more people. The company has been carbon neutral in its own operations since 2020. All new product introductions are designed in line with the company’s EcoDesign requirements by 2025, and it aims to generate 25% of its revenue from circular products and services by 2025. Societally, it aims to improve the health and well-being of 2 billion people per year by 2025, including 300 million people in underserved communities, and 1 million workers in its supply chain.

References

[1] Results from case studies are not predictive of results in other cases.
– Jackson and Health System: The LCA results are obtained using Philips Environmental Profit & Loss (EP&L), proxy data, literature and customer obtained data. The LCA is not validated externally by 3rd party.

– Champalimaud Foundation and Rennes CHU: The LCA results are obtained using Philips Environmental Profit & Loss (EP&L), proxy data, literature and customer obtained data including energy measurements. The LCAs are validated externally by 3rd party.

[2] EDGAR—Emissions Database for Global Atmospheric Research Emissions Data and Maps 2018 http://edgar.jrc.ec.europa.eu/

Top-Rated Sculptra Clinics in London: Enhance Your Skin’s Vitality

Sculptra Clinics in London:

Are you looking to rejuvenate your skin and bring back its youthful glow? Finding the right clinic is key. This article will guide you through some of the best Sculptra London clinics. By the end of this read, you’ll have a clearer idea of the top-rated Sculptra Clinics in London and where to go to achieve the vibrant skin you desire. Let’s explore the options available in this bustling city.

Sculptra: What it is and How it Works

Sculptra Clinics In London

Sculptra is a cosmetic injectable used to restore facial volume lost due to aging or other factors. Unlike other fillers, it stimulates collagen production, leading to natural-looking results over time.

The process involves injecting poly-L-lactic acid into the deep dermis layer of the skin. This triggers the body’s natural collagen production, which helps to restore the structure of the skin.

The full effect usually becomes apparent after a few months as the collagen forms stronger support structures under the skin.

Leading Clinics in London Offering Sculptra Treatments

Here are some top-rated clinics in London known for their expertise in administering Sculptra treatments.

Harley Street Skin Clinic: Stellar Reputation and Expertise

Harley Street Skin Clinic is synonymous with top-notch cosmetic treatments in London. Their team comprises highly skilled professionals who specialize in various aesthetic procedures, including Sculptra injections.

Linia Skin Clinic: Cutting-Edge Techniques and Personalized Care

Linia Skin Clinic is another top contender when it comes to Sculptra treatments in London. Known for utilizing cutting-edge techniques, this clinic offers personalized care tailored to each patient.

Esculap Clinic: Excellence in Aesthetic Medicine

Esculap Clinic has earned a reputation for excellence in aesthetic medicine in London. This clinic combines innovative treatments with exceptional patient care to deliver superior results.

Viva Skin Clinics: Holistic Approach and High Client Satisfaction

Viva Skin Clinics stands out for its holistic approach to skincare. They offer comprehensive consultations and tailor-made plans designed to enhance each client’s natural beauty through Sculptra treatments.

Factors to Consider When Choosing a Sculptra Clinic

Selecting the right clinic for Sculptra treatments involves more than just looking at expertise and reputation. Here are some important factors to keep in mind:

  • Credentials and Experience of Practitioners: Ensure that the professionals administering the treatments have proper training and substantial experience specifically with Sculptra injections.
  • Practitioner Backgrounds: Research or ask about the backgrounds of the practitioners during your consultation. Look for board-certified doctors or nurses who specialize in cosmetic injectables.
  • Facility Standards and Safety Protocols: Choose a clinic that adheres to all health regulations and ensures that all procedures are done in sterile environments.
  • Affordability Without Compromising Quality: While cost shouldn’t be the only deciding factor, it’s important to know how much you’re willing to spend without compromising on the quality of treatment.
  • Budget Planning for Your Treatments: Many clinics offer initial consultations where they discuss costs based on your individual needs and desired outcomes. Use these consultations to find out what fits within your budget while still ensuring high-quality service.

Conclusion

Choosing the right clinic for Sculptra treatments in London can make a big difference in both your results and overall experience.

Whether you’re drawn to the renowned expertise at Harley Street Skin Clinic, the advanced techniques at Linia Skin Clinic, the high standards of Esculap Clinic, or the holistic care at Viva Skin Clinics, each offers unique advantages to rejuvenate your skin.

When making your decision, keep in mind factors like the credentials of the practitioners, the safety standards of the facility, and the overall affordability.

This approach ensures you find a clinic that fits both your needs and your budget, leading to a satisfying and effective treatment experience.

How IV Hydration Can Improve Your Overall Health and Wellbeing

IV Hydration

Staying healthy and taking care of our body has never been more important. We all know the basics of good health: drinking plenty of water, eating the right foods, and exercising regularly. But have you ever heard about IV hydration? It’s a popular method that many people use to improve their health and wellbeing quickly and effectively. This article will explain what IV hydration is, how it works, and how it can make a big difference in your overall health.

What is IV Hydration?

IV hydration, also called intravenous hydration, involves delivering fluids directly into your bloodstream through a small needle. The “IV” stands for “intravenous,” meaning the fluid goes directly into a vein. This method allows your body to absorb fluids, vitamins, and minerals much faster than drinking water or taking oral supplements. Because the fluids bypass your digestive system, they get into your bloodstream immediately, making IV hydration a quick and efficient way to rehydrate and nourish your body.

How Does IV Hydration Work?

IV hydration works by using a simple, sterile drip that delivers a specific mixture of fluids, electrolytes, and vitamins directly into your bloodstream. The process takes about 30 to 60 minutes and is done by a trained medical professional. Since the fluids are delivered straight into the bloodstream, your body can use them right away, giving you faster and more effective results compared to traditional methods of hydration.

Why Hydration is Important for Health

Before diving into the benefits of IV hydration, it’s important to understand why hydration is key to good health. Water makes up about 60% of our body, and every system in our body depends on it. Proper hydration helps with:

  • Regulating body temperature
  • Lubricating joints
  • Protecting organs and tissues
  • Carrying nutrients and oxygen to cells
  • Flushing out toxins
  • Supporting digestion and nutrient absorption

When we don’t drink enough water, we can become dehydrated. Even mild dehydration can lead to problems like fatigue, headaches, poor concentration, and mood changes. Severe dehydration can cause more serious health problems, like kidney stones, urinary tract infections, and even heatstroke.

Common Causes of Dehydration

Many things can cause dehydration, and some are more common than we think. Here are a few examples:

  • Not drinking enough water: This is the most obvious cause. Many of us don’t drink as much water as we should, especially when we’re busy or distracted.
  • Exercise: When we exercise, we sweat and lose water and electrolytes. If we don’t replace those fluids, we can become dehydrated.
  • Illness: Fever, vomiting, and diarrhea can all cause rapid fluid loss, making it harder for the body to stay hydrated.
  • Hot weather: In warm climates, our bodies lose more water through sweat.
  • Alcohol: Alcohol is a diuretic, which means it causes your body to lose water faster.

The Benefits of IV Hydration

IV hydration offers several benefits that go beyond simply drinking water. Here’s how it can improve your overall health and wellbeing:

1. Fast and Effective Hydration

One of the biggest benefits of IV hydration is how quickly it works. When you drink water, it can take time for your body to absorb it, especially if you are dehydrated. With IV hydration, the fluids go directly into your bloodstream, so your body can start using them immediately. This is especially helpful if you’re recovering from illness, an intense workout, or dehydration caused by other factors.

2. Boosting Energy Levels

Dehydration can make you feel tired and sluggish. When you’re not getting enough water, your body has to work harder to carry out its normal functions. IV hydration can quickly restore your fluid balance, giving you a much-needed energy boost. Many people report feeling more awake, alert, and refreshed after a session of IV hydration.

3. Supporting Immune Health

Certain vitamins and minerals, like vitamin C and zinc, play a key role in keeping your immune system strong. IV hydration can deliver these nutrients directly into your bloodstream, giving your body the tools it needs to fight off illnesses. This can be especially helpful during cold and flu season or when your body needs an extra boost to stay healthy.

4. Improving Skin Health

Hydration plays a big role in the health and appearance of your skin. When you’re dehydrated, your skin can look dry, dull, and tired. IV hydration can improve skin elasticity, reduce the appearance of wrinkles, and give your skin a healthy, glowing look by delivering hydration from the inside out.

5. Hangover Relief

A common use of IV hydration is to treat hangovers. When you drink alcohol, it can dehydrate your body, leading to symptoms like headaches, nausea, and fatigue the next day. A hydration IV can quickly replenish the fluids and electrolytes you lost, helping you feel better faster.

6. Speeding Up Recovery

Whether you’re recovering from a workout, surgery, or illness, your body needs extra fluids and nutrients to heal properly. IV hydration can deliver a high dose of vitamins, minerals, and fluids that can speed up the recovery process. It’s especially helpful for athletes or anyone recovering from strenuous physical activity.

Who Can Benefit from IV Hydration?

Many people can benefit from IV hydration, especially those who are prone to dehydration or have special hydration needs. Here are a few groups who might find it particularly useful:

  • Athletes: People who exercise intensely lose more fluids and electrolytes than the average person. IV hydration can help them recover faster after a workout and prevent dehydration during periods of intense training.
  • People with chronic illnesses: Conditions like Crohn’s disease, celiac disease, and others that affect the digestive system can make it harder to stay hydrated. IV hydration can be an effective way to get the nutrients and fluids that the body needs without relying on the digestive system.
  • Frequent travelers: Long flights, especially in dry airplane cabins, can leave you feeling dehydrated. Travelers often use IV hydration to recover from jet lag and stay hydrated during their trip.
  • Hangover sufferers: IV hydration is becoming a popular treatment for hangovers, as it quickly replenishes lost fluids and helps relieve symptoms like nausea and headaches.
  • People recovering from illness: If you’re recovering from a cold, flu, or stomach bug, IV hydration can help you bounce back faster by giving your body the fluids and nutrients it needs.

Types of IV Hydration Solutions

There are different types of IV hydration solutions, each tailored to specific needs. A healthcare professional will help you choose the right one based on your situation. Here are some of the most common types:

  • Basic hydration solution: This solution contains sterile water with a mix of electrolytes, like sodium and potassium, which are essential for balancing the fluids in your body.
  • Vitamin infusion: This type of IV hydration includes vitamins and minerals, such as vitamin C, B vitamins, and zinc, to boost your immune system and energy levels.
  • Detox solution: These infusions often contain antioxidants, like glutathione, which can help your body detoxify and remove harmful substances.
  • Recovery solution: Designed for athletes or those recovering from surgery, this solution contains amino acids and other nutrients that support muscle recovery and tissue repair.

How Often Should You Get IV Hydration?

How often you get IV hydration depends on your personal needs and health goals. Some people get it regularly as part of their wellness routine, while others use it as needed—for example, after a workout, during a hangover, or when recovering from an illness. It’s important to talk to a healthcare professional to determine the right schedule for you.

Are There Any Risks?

IV hydration is generally safe when performed by a trained healthcare professional. However, like any medical procedure, there are some potential risks, including:

  • Infection: Anytime a needle is inserted into the skin, there is a small risk of infection. This is why it’s important to have IV hydration done in a clean, sterile environment by a professional.
  • Bruising or discomfort: Some people may experience mild bruising or discomfort at the site where the needle is inserted.
  • Electrolyte imbalances: In rare cases, an incorrect balance of fluids or electrolytes can lead to issues like low sodium levels (hyponatremia) or high potassium levels (hyperkalemia). This is why it’s important to have IV hydration administered by a trained healthcare provider.

Conclusion

IV hydration is a powerful tool that can improve your overall health and wellbeing. Whether you’re looking for a quick energy boost, better skin, faster recovery from exercise, or relief from a hangover, IV hydration offers a fast and effective solution. While it may not replace the need to drink water regularly, it can provide a valuable supplement when your body needs more than what you can get from food and water alone. As always, it’s important to talk to a healthcare provider to determine if IV hydration is right for you and to ensure it’s administered safely and effectively.

At Pack Expo, Schreiner MediPharm Will Showcase New RFID Labels with Digital Seal Function

Schreiner MediPharm

Schreiner MediPharm, a Germany-based global provider of innovative functional label solutions for the healthcare industry, will showcase its new RFID label with digital first-opening indication at Pack Expo 2024, November 3-6 in Chicago. The new solution – which irreversibly indicates a container’s initial opening, and enables automated integrity tracking – will be among those displayed at the company’s Booth W-16094.

Digitization and process automation are increasingly sought-after in healthcare settings, as such setups increase product safety and avoid medication errors. Labels with integrated RIFD chips can play an important role, since they are used for product marking while simultaneously enabling unique unit-dose digital IDs. This is a decisive prerequisite for complete end-to-end tracking of containers within the supply chain. However, in hectic hospital settings it must also be ensured that the integrity of prefilled syringes or vials has not been compromised prior to medication administration.

Schreiner MediPharm’s new RFID label comprises an integrated digital sealing function whose design irreversibly indicates a container’s initial opening, and enables automated integrity tracking. This eliminates the need to manually check whether the container has already been opened. This not only makes work easier for medical staff, but also optimizes inventory management, since unused medication can be efficiently returned to stock. At the same time, possible diversions and medication misuse can be monitored.

Schreiner MediPharm’s new label features a special design that reliably protects the integrated chip from mechanical stress and impact during the pharmaceutical production process; this buffering effect can pay particular dividends for manufacturers utilizing high-speed dispensing systems. The result is a digital seal that can be reliably read from production to final application – an important aspect in ensuring seamless unit-level medication tracking for increased product and patient safety.

Also at Pack Expo, Schreiner MediPharm will highlight recently introduced label solutions for applications with sensitive APIs, as well as its latest sustainability-minded product solutions. For example, the company’s Needle-Trap Secu combines needlestick safety elements with an integrated first-opening indication – a setup that eliminates the need for an additional blister pack, resulting in considerable space savings as well as reduced waste and cost.

OrganOx metra® System Approved for Liver Transplantation in Canada

OrganOx Ltd, a world-leading organ medical technology company, today announced Health Canada has approved the OrganOx metra® System for use during liver transplantation. The OrganOx metra® System is currently commercially available for liver transplantation in the U.S., the U.K., and the European Union. The company plans to commercially launch the system in Canada in 2025.

The OrganOx metra® System utilizes normothermic machine perfusion, or NMP, to circulate oxygenated blood, medications, and nutrients to donated organs at normal body temperature and near physiological conditions. This innovative technology extends organ preservation time, allows pre-transplant clinical assessment of organ viability and can dramatically improve operational logistics for both transplant teams and patients.1

“We are thrilled to receive this authorization in Canada, further advancing our vision to improve clinical outcomes for liver transplant patients around the globe,” said Craig Marshall, CEO of OrganOx. “In the coming months we look forward to introducing the metra® to transplant centers across Canada.”

The performance of the metra® system has been evaluated across several clinical trials including the Consortium for Organ Preservation in Europe (COPE) European Trial, the first randomized trial to assess machine perfusion versus static cold storage in liver transplantation. Compared with static cold storage, the OrganOx metra® achieved a 50% lower level of graft injury despite a 54% longer mean preservation time.2

Celaid Therapeutics Inc. Secures up to $19M Grant from the Japanese Agency for Medical Research and Development

Celaid Therapeutics Inc. announced today that it has been awarded up to approx. 2.7 billion yen ($19M USD) in non-dilutive grant funding as “Strengthening Program for Pharmaceutical Startup Ecosystem” program by the Japanese Agency for Medical Research and Development (AMED). The grant will be used to support the development of Celaid’s lead program “CLD-001”, an ex vivo expanded Hematopoietic Stem Cell (HSC) Therapy for pediatric non-malignant diseases.

“The Japanese government has announced that it will provide funding support for pharmaceutical startups over the next five years through 300 billion yen ($2.1 Billion USD) grant as Strengthening Program for Pharmaceutical Startup Ecosystem program. Being selected for this program is a vote of confidence in our product and our company.” said Nobuyuki Arakawa, Celaid’s President and CEO.

Through this grant program, Celaid will reinforce non-clinical and clinical development of CLD-001 in the US. and accelerate development to deliver CLD-001 to patients suffering from pediatric non-malignant diseases worldwide as soon as possible.

About CLD-001, an ex vivo expanded Hematopoietic Stem Cell (HSC) Therapy

CLD-001 is being developed as a hematopoietic stem cell therapy product for severe pediatric non-malignant disease. Rare blood diseases such as aplastic anemia, primary immunodeficiency, inherited metabolic disorder, and sickle cell disease, which start in childhood and are associated with various physical and neurological complications, have a very poor prognosis. Currently, the only curative therapy is allogeneic hematopoietic stem cell transplantation (HSCT). On the other hand, there are still significant unmet needs for allogeneic HSCT due to donor problems such as bone marrow donor shortage and HLA type mismatch, as well as side effects such as transplant-related mortality and graft-versus-host disease (GvHD).

CLD-001 is a hematopoietic stem cell product that solves the donor problem, side effects, and disadvantages described above.

In addition to solving the donor problem by using frozen cord blood stored in a cord blood bank as the cell source, CLD-001 also solves the bottleneck of low HSC counts in cord blood with our proprietary HSC expansion technology, enabling us to provide HSCs with the best HLA type for the patient. CLD-001, the HLA best-match and bone marrow-constructible HSCs, is expected to significantly improve overall survival after HSC therapy.

Celaid Therapeutics Overview

Celaid Therapeutics Inc. is a startup born out of the University of Tokyo and University of Tsukuba with proprietary technology for selective ex vivo HSC expansion. By safely and efficiently expanding human HSCs, Celaid aims to provide the next generation of cell and gene therapy products for cell therapy targeting hematologic disease, ex vivo HSC gene therapy for genetic disorders, and angiogenesis for ischemic diseases.

Yourgene Health and Genetix Launch First Local Non-invasive Prenatal Testing Service in Colombia

Yourgene Health (part of the Novacyt group of companies), a leading international molecular diagnostics group, has installed the first non-invasive prenatal testing (NIPT) workflow in Colombia at Genetix, a high-tech medical organisation specialised in human genetic diagnosis. Genetix introduced its NipTest at a launch event held in Bogotá, Colombia yesterday evening to raise awareness of this new local NIPT provision to clinicians in the region.

The service will utilise Yourgene’s IONA® Nx NIPT Workflow to deliver fast, accurate NIPT results for expectant parents in Colombia, helping to reduce turnaround times and shipping problems.

Utilising Yourgene’s IONA Nx NIPT Workflow offers Genetix a complete CE-marked in vitro diagnostic (IVD) device to establish its own quality-assured prenatal screening service in-house. The IONA test has been validated on a highly flexible and scalable workflow, suitable for low- to high-volume sample throughput, enabling the growing clinical laboratory to meet rising demands.

The NIPT is performed using cell-free placental DNA from maternal blood to screen for aneuploidies: trisomy 21 (Down’s syndrome), trisomy 18 (Edwards’ syndrome) or trisomy 13 (Patau’s syndrome), and can also be used to determine the sex of the fetus. The analysis is performed using next-generation sequencing technology, with test results available in three days.

Previously, blood samples collected in Colombia were sent to the USA for testing, delaying turnaround times and increasing costs with additional shipping expenses. By offering access to its NipTest locally, Genetix will help to ensure expectant parents receive reliable results quickly, while reducing the need for invasive tests and the associated stress and anxiety.

Lyn Rees, Executive Director, Yourgene Health, said: “We are thrilled to support Genetix by enabling them to deliver an advanced prenatal screening solution locally to the pregnant mothers in Colombia. We look forward to a long and fruitful relationship with their pioneering team.

We are immensely proud, once again, to be contributing to patient care where it is needed. Yourgene is committed to delivering best-in-class NIPT solutions and continues to be a leading player in the global market and a trusted provider.”

Dr Claudia Serrano, General and Scientific Director, Genetix, said: “We are excited to offer this non-invasive test for the first time in Colombia and are delighted to have the backing of our esteemed partners, Yourgene Health.

We strive to advance diagnostic services and transform prenatal genetics in our country and the launch of the NipTest is testament to this. Yourgene’s quality-assured IONA Nx NIPT Workflow empowers us to deliver fast, accurate and reliable NIPT solutions, helping us to improve the lives of our patients and their families.”

For more information about Yourgene’s IONA Nx NIPT Workflow, please visit: https://yourgenehealth.com/our-products/nipt-solutions/nipt/the-iona-test/

Conformal Medical Announces Launch of the GLACE Study with Next-Gen CLAAS® AcuFORM™ Left Atrial Appendage Occlusion Device

Conformal Medical, Inc. today announced the initiation of the GLACE Study. This European study* aims to assess the use of intracardiac echocardiography (ICE) imaging of the left atrial appendage (LAA) during appendage closure procedures with the next-generation CLAAS® AcuFORM™ device in patients with non-valvular atrial fibrillation. The prospective, multicenter, non-randomized, single-arm investigation will enroll approximately 80 patients in Denmark, Italy, and the Czech Republic.

Initial patients were treated by the study’s co-principal investigators Professor Jens Erik Nielsen-Kudsk, M.D. of Aarhus University Hospital and Professor Ole De Backer, M.D. of Rigshospitalet, Copenhagen University Hospital at their respective institutions in Denmark. Additionally, Shephal Doshi, M.D., from Providence Saint John’s Health Center and the Pacific Heart Institute in Santa Monica, California and Principal Investigator of the CONFORM Pivotal Trial was present for the initial cases.

“I am excited about the new CLAAS AcuFORM implant and the ability to confirm seal with angiography providing procedural confidence, ensuring the patient has been properly treated,” stated Nielsen-Kudsk. “ICE has become our primary imaging platform for LAAO, the GLACE Study allows us to validate the use of ICE with this innovative technology.”

ICE imaging facilitates real-time visualization of cardiac structures during LAAO closure, enhancing precision while reducing radiation exposure and procedure time. This approach often eliminates the need for general anesthesia, improving patient comfort and operational efficiency.

“The CLAAS AcuFORM device enhances and simplifies the procedure, with only two sizes, one of which effectively treats over 90% of patients,” stated Dr. Doshi. “Simplified sizing and ease of use enabled by this device will drive improved workflow in the lab.”

Designed to optimize anchor penetration and featuring an improved ePTFE material, and a simplified delivery system, the CLAAS AcuFORM LAAO System builds upon the novel CLAAS device and is engineered to conform to and seal the LAA with its proprietary foam-based architecture. The implant addresses the clinical spectrum of LAA anatomies with only two sizes. The system aims to simplify delivery and eliminate the need for procedural transesophageal echocardiogram (TEE) so that physicians may perform the procedure without general anesthesia, a significant advancement with the potential to shift clinical practice to a same-day, single-operator procedure. Over 350 patients have been successfully implanted with the Conformal CLAAS System as part of early feasibility studies and the ongoing CONFORM Pivotal Trial.

“The use of ICE imaging in LAAO is growing significantly and will continue,” said James Reinstein, President and CEO of Conformal Medical. “Our next-generation LAAO technology conforms to individual anatomies, enabling clinicians to simplify the procedure with 2 sizes, the ability to confirm seal, and eliminate general anesthesia & intubation.”

Overcoming Obstacles: How To Remake Yourself After Addiction Treatment

Addiction Treatment

Embarking on a journey to rebuild your life after addiction treatment is both challenging and rewarding. It’s a time to reflect on past experiences and foster positive changes that will shape your future. As you navigate through this transformative period, developing strategies and adopting new habits become crucial to prevent relapse and ensure lasting recovery. Keep reading to discover the path to personal rejuvenation and sustained well-being.

Managing Relapse Triggers and Stressors: Strategies for Resilience

Long-term recovery from addiction is about more than abstaining from substances; it involves managing triggers and stressors effectively. Awareness of personal triggers is essential, as is developing strategies for navigating challenging situations without reverting to old habits. Creating a plan with a counselor or within a support group can provide the right tactics for handling stressors as they arise.

Establishing healthy boundaries is another critical aspect of managing triggers. Knowing when to say ‘no’ and protecting yourself from high-risk scenarios are skills that must be honed for successful recovery. This might include distancing from certain relationships or environments that could jeopardize sobriety.

For some, professional support from a drug and alcohol rehab in Texas or your area may be critical in managing relapse triggers. These facilities provide a structured environment and professional guidance, allowing for focused recovery efforts. The professional support extends beyond the initial treatment, contributing to a robust, long-term defense against relapse.

Embracing the New You: Steps To Personal Rejuvenation Post-Addiction Treatment

Recovery from addiction opens a new chapter in life, urging you to develop a refreshed sense of self. Embracing the new you begins with self-acceptance and the acknowledgment of personal growth during the recovery. This process can be both empowering and humbling, allowing you to look forward with optimism. Personal rejuvenation often starts with taking care of your physical health and recognizing the remarkable resilience of the human body.

Mental and emotional well-being are equally important for a holistic approach to self-renewal. Engaging in activities such as meditation, counseling, or journaling can be therapeutic and reinforce your inner strength. These practices contribute to heightened self-awareness and support a balanced mental state. They also can be pivotal in addressing underlying issues, preventing them from undermining your progress.

Continuing education or career advancement can also be a significant aspect of self-development. Pursuing an associate degree in public health or other educational opportunities provides a sense of purpose and direction. Such forward-thinking decisions reinforce your new identity and the positive changes you’ve made, grounding you in the sober life you’ve chosen.

Rediscovering Passions and Pursuing New Interests

3987

Post-treatment life presents an opportune moment to rediscover old passions and explore new interests. Hobbies and leisure activities that were once sidelined by addictive behaviors can now be revisited and enjoyed with a clear mind. Whether it’s playing a musical instrument, painting, or hiking, indulging in these passions can bring profound joy and satisfaction.

Taking on new pursuits is also instrumental in establishing a fulfilling life in recovery. Engaging in volunteer work, learning new skills, or even traveling can expand your horizons and offer fresh perspectives. These experiences can serve as building blocks for a new, healthier lifestyle and identity.

The act of learning can itself be a powerful therapeutic tool. Taking up educational courses or workshops not only broadens your knowledge but can also boost self-esteem and confidence. The sense of accomplishment from learning is a testament to your ability to create positive change in your life.

Celebrating Milestones and Setting Goals for a Brighter Future

Celebrating milestones is a pivotal component of the recovery process. Acknowledging sobriety anniversaries, accomplishments in personal growth, and recovery-related achievements reinforces your commitment to maintaining a substance-free lifestyle. Every milestone is an opportunity to reflect on how far you’ve come and the effort invested in reaching these points.

Goal-setting plays a crucial role in shaping a future that aligns with your values and aspirations. Establishing short-term objectives can build momentum and provide a clear direction for your ongoing efforts. As these goals are realized, larger, long-term ambitions become more attainable, painting a progressive picture of future potential.

Altogether, successful recovery from addiction requires adopting a multifaceted approach that encompasses personal rejuvenation, building a supportive community, rediscovering passions, managing triggers, and celebrating progress. Overall, these elements combine to chart a path not only to recovery but to a life of substance and fulfillment beyond what may have been imaginable during the grips of addiction.