Tele: 561.316.3330
Breaking Medical Device News

Thursday, October 21, 2021


HomeACTPHAST4RRetinal-imaging Breakthrough That Can Swiftly Detect Eye Diseases

Retinal-imaging Breakthrough That Can Swiftly Detect Eye Diseases

November 27, 2020

Retinal-imaging: Glaucoma, cataracts, or macular degeneration will be quicker and easier to diagnose thanks to a new scanner being developed to capture real-time and artefact-free eye images.

European researchers are developing a new real-time scanner that will create a full image of a moving eye without any blurring. Teaming up with photonics innovation hub ACTPHAST 4R the scientists at Vrije Universiteit (VU) Amsterdam are progressing their scanner concept to a demonstrator stage to acquire data faster than existing optical imaging technologies.

Some degenerative eye conditions like glaucoma, diabetic retinopathy, macular holes, and retinal diseases can progress to blindness if they are not diagnosed in their early stages due to missed opportunities from poor image quality or motion artefacts.

Eye specialists currently use an imaging technique called Optical Coherence Tomography (OCT), a non-invasive test that uses light to build up an image of the retina by capturing cross-sectional ‘slices’.

However, because the eye is constantly moving, the images suffer from blurring and often only partial pictures are possible. OCT technology has never been fast enough to take a full image of a moving eye without blurring or expecting the patient to sit incredibly still.

The lead researcher on this breakthrough development, Assistant Professor Imran Avci from the Department of Physics and Astronomy at VU Amsterdam, said: “Diagnoses of eye diseases that could lead to blindness require good quality images at an early stage.

“Eye abnormalities can be so very subtle in the early phase that standard OCT can miss these tiny changes. Because our eyes are constantly moving to refresh the visual input, even at a microscopic level, it makes eye imaging very difficult without having blurred images.

“Our scanner is different: with the data acquired fast enough, the overall goal is to have a real-time imaging system. The rapid switch will enable us to perform real-time high quality moving footage, or a ‘video’ of your eye.”

Light Bundles  

The scanner works by acquiring data from the light signal at rapid speeds by ‘bundling’ groups of information together.

“Our new scanner will acquire the light signal data at least a hundred times quicker than OCT systems that exist today.

“Taking 100 to 120 reference points, our scanner ‘bundles’ them together, acquiring 20 arms at a time. However, it is our patented ‘switch’ that moves from bundle to bundle in nanoseconds that gives us the ability to quickly acquire the images in real-time.”

Standard OCT works by collecting data from a single sample arm, which is acquired mechanically using a scanner. The final image is formed by combining these individual images during post-processing.

“Processing each sample arm means existing technology is not fast enough to handle constant eye movement.

“We can speed up the traditional OCT imaging system while keeping its sensitivity at a reasonable value. Our imaging speed improves while the signal to noise ratio is not sacrificed too much. The faster speed makes it possible to image dynamic situations or fast-moving parts of the body, like the eye.

“The OCT we have today uses a process called ‘eye-tracking’ which can be tricky and involves many elements to do it right. However, if we can manage to create an image before the eye moves (in 5-10 sec or so) then there is no need for tracking schemes,” said Dr. Avci.

ACTPHAST for Researchers 

Working with ACTPHAST 4R – an EU innovation hub designed to give researchers working in academia throughout Europe access to top-level expertise and technologies in photonics to produce demonstrators for their scientific breakthroughs, similar to the supports provided by the separate ACTPHAST 4.0 innovation hub for European companies, especially for SMEs – Dr Avci’s team has been able to access the right technical and business coaching expertise to advance the scanner concept towards an actual product.

ACTPHAST 4R Coordinator, Prof Hugo Thienpont of the Brussels Photonics Team (B-PHOT) at Vrije Universiteit Brussel (VUB) said: “Researchers like Dr Avci do not have easy access to the relevant cutting-edge photonics expertise and technologies within their own universities or even their own regions.

“The ACTPHAST 4R support is crucial to bridging the gap between concept and demonstrator. Only an innovation hub like ACTPHAST 4R can provide the unique cross-border connections for bridging the innovation valley of death and accelerated TRL advancement.

“At this early stage for researchers, it means turning their scientific concepts into practical demonstrators which are cutting-edge and industrially relevant.

If the demonstrator is successful, then they can look at commercialization options such as licensing or a spin-out company from the university, and taking it to the next stage of a working prototype”.

Dr. Avci said: “ACTPHAST 4R has been essential in helping us develop our product because it has de-risked the investment we have to make. ACTPHAST 4R has given us access to the right know-how and equipment to overcome critical photonics challenges, including the invaluable opportunities for hands-on training at the facilities of the top competence centers in the key photonics technologies for our application. They make a huge difference to small research teams like ours”.

Specializing in the deployment of cutting-edge photonics technologies, ACTPHAST 4R gives researchers in academic institutes all over Europe the chance to turn their breakthrough scientific concepts into fully-functioning industrially-relevant demonstrators.

 “As a ‘one-stop-shop’ solution for researchers innovating in photonics, ACTPHAST 4R provided rapid access to the technical specialists and cutting-edge technologies in photonics that the team needed in order to further develop the product, and also substantially funded the innovation work. The application process via the ACTPHAST 4R website was quick and easy too”.

ACTPHAST 4R operates a continuous open call for researchers who wish to apply for innovation support. Applications can be made online via the ACTPHAST 4R website at the following link:

Medical Device News Magazine
Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

Stay Connected


Don't Miss

Contraline Closes $10.7 Million Series A Financing to Become a Clinical Stage Company

This infusion of capital will support the initiation of a first-in-human trial of ADAM™, the world’s first hydrogel implant designed to provide long-lasting, non-permanent contraception for men.

Adam S. Epstein New CEO of AliMed, Inc.

In his prior role as Chief Commercial Officer, Epstein directed all customer-facing, demand generation and product development activities. Under his new leadership, AliMed will continue to build a robust portfolio of contracted positions with major, national GPO’s, IDN’s, and Distribution partners to drive sales growth.

Tony Collins Appointed CFO of Xenter

“Xenter is building a platform for medical innovations that is transformational. The only way we can achieve our objectives is if we have great leaders like Tony Collins leading our company,” stated Richard J. Linder, Founder, Chairman & CEO of Xenter, Inc. “Tony brings incredible depth and experience to his new role as Chief Financial Officer.

Scott Sexton Appointed President at FIGUR8

"Scott brings to FIGUR8 30 years of workers' compensation, casualty, disability, and commercial health experience, most recently serving as a market leader for CorVel's national carrier practice sales team," said Nan-Wei Gong, CEO, and co-founder of FIGUR8.

Insulet Announces Board of Director Changes with Appointment of Luciana Borio, M.D. and Retirement of Sally W. Crawford

Luciana Borio MD is a respected physician with vast experience in advancing major regulatory and policy agendas for the United States.

Ganymed Robotics Awarded a €2.5M Grant from the EC through the EIC Accelerator Program

Ganymed Robotics is developing a radically new approach to surgical robotics by combining computer vision, a branch of artificial intelligence, and mechatronics.

By using this website you agree to accept Medical Device News Magazine Privacy Policy