Deciphex Rolls Out Automated Image Quality Control for Digital Research Pathology

Faster Study Delivery with Patholytix Automated Image QC will speed up the entire research and drug development process by removing today’s common barriers and choke points in studies and development.

Summation

  • We believe that an automated QC tool would not only increase the efficiency of the lab (less time for WSI review) but also mitigate the possibility of identifying WSI issues at the time of pathologist review”.
  • For example, if 10% of slides in a study have QC issues, the tool can cut the histotech's workload down by 90% as they would only need to manually review these slides.
  • The Patholytix Image QC tool not only allows the histotech to manually review less slides, but also guarantees that the targeted QC issues will be in this subgroup of flagged slides.

By building Automated Image QC into Patholytix 3.0, Deciphex delivers dramatically faster turnarounds of studies.

In today’s world, histotechnicians spend a significant amount of time performing manual QC.

This has numerous downstream effects:

  • Pathologists must wait while slides are re-scanned

  • Histotechnicians must re-scan, and review reworked slides, increasing their workload

  • Study delivery times, and in turn, study completion times, are delayed

  • Delays at the preclinical stage of drug development lead to delays getting the drug to market

MANUAL QC PUTS STUDY AT RISK

Dr. Dan Rudmann, Global Director of Digital Toxicologic Pathology at Charles River Laboratories, and global strategic partner of Deciphex, tells this anecdote:

“The manual review of whole slide images (WSI) is slow and consistency is difficult. On the final day of study review for low and mid-dose animals for a recent study, I identified issues with a few WSI that required rescanning. The scanner was booked and the rescans were delayed by a day. This rework late in the primary diagnostic timeline puts the study timelines at risk which is not something we want to do. We believe that an automated QC tool would not only increase the efficiency of the lab (less time for WSI review) but also mitigate the possibility of identifying WSI issues at the time of pathologist review”.

Patholytix eliminates the delays that have caused manual QC to put studies at risk.

AUTOMATIC SELECTION OF CLEAR IMAGES FOR REVIEW

The Patholytix Automated Image QC module prechecks all study slides for blurring, striping and other artefacts. Whole slide images of good quality are sent to the pathologist for immediate review. Those that are of poor quality are flagged for manual review to determine if re-work is needed. For example, if 10% of slides in a study have QC issues, the tool can cut the histotech’s workload down by 90% as they would only need to manually review these slides.

Often a histotech only reviews a proportion of slides to check for QC issues rather than the full study. Although this is more time efficient, there is a risk of missing QC failures in the unreviewed slides. The Patholytix Image QC tool not only allows the histotech to manually review less slides, but also guarantees that the targeted QC issues will be in this subgroup of flagged slides.  This streamlines workflow, while also giving more confidence in QC decisions.

All of this happens at the point of upload, meaning a histotech can review flagged slides immediately. Not only does this workflow offer significant time savings through its ability to detect QC anomalies across a study sooner, but it also speeds up the manual review of each image itself. Within the Patholytix QC Viewer, coloured mask overlays direct a Histotech’s attention to the area in the image causing the QC fail. This saves a user time looking through a slide for an issue, which can take minutes to detect. With the mask they can identify the region in seconds, saving them a significant amount of time per slide.

FEWER FALSE POSITIVES

Some scanners have built in QC methods. However, they tend to detect a lot of slides that are below thresholds that would impact a pathologist’s review, leading to false positives. By flagging more slides for histotechs to review, they spend a considerable amount of time performing manual QC.

The Patholytix Automated Image QC tool detects less false positives, leaving histotechs with less slides to manually review.

USER ADJUSTABLE THRESHOLDS

Users can adjust the sensitivity thresholds so that the software only selects slides they themselves would consider needing re-work, or those they consider good to be sent directly to the pathologist.

ACCELERATED DUE DILIGENCE

The due diligence required for a GLP study means that some organisations will review a higher proportion of these slides. In fact, it’s not unknown for organisations to review 100% of slides to be sure there are no artefacts.

Image QC automation will have a dramatic impact on drug development programs.

Deciphex offers a range of services for clinical and research pathology, including its Patholytix platform for research pathology, and its Diagnexia clinical service, which provides remote subspecialty pathology services. The company’s solutions have already been adopted by leading research organisations and pharmaceutical companies, and its products are trusted by customers around the world.

In December 2022, Deciphex introduced digital pathology review and scoring in a single platform for the first time. The research platform Patholytix 3.0 means that for the first time, Research Pathologists can review and score non-clinical studies on a single platform, resulting in faster pathology reviews, with less risk of error. Today’s launch of Automated Image QC is yet a further step as part of the company’s mission to integrate and enhance Pathologists’ capability to deliver their skills at scale.

Medical Device News Magazinehttps://infomeddnews.com
Medical Device News Magazine provides breaking medical device / biotechnology news. Our subscribers include medical specialists, device industry executives, investors, and other allied health professionals, as well as patients who are interested in researching various medical devices. We hope you find value in our easy-to-read publication and its overall objectives! Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

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