Saturday, September 23, 2023
Saturday, September 23, 2023

Inomagen Therapeutics Awarded $1.6 million NIH SBIR Phase 2 Grant

Inomagen Therapeutics (formerly Rhythm Therapeutics) announced the approval of the company’s Phase 2 Pre-Clinical segment – NIH SBIR Fast Track Award totaling $1,636,504 million.

Inomagen Therapeutics notes that the proceeds from the award will be utilized to continue the advancement of the company’s novel gene therapy for the treatment of atrial fibrillation (AF), the world’s most common arrythmia. Future milestones to be achieved under the Phase 2 award include determining the optimal doses of gene attenuating electrical and structural remodeling in large animal models of AF.

AF is characterized by an irregular and often rapid heart rate occurring when the two upper chambers of the heart experience chaotic electrical signals resulting in irregular heart rhythm. AF is a growing epidemic straining healthcare resources with 6 million people in the U.S. afflicted and prevalence expected to grow to >10 million by 2035.

Current treatment regimens include performing cardiac ablation which burns patient heart tissues to alleviate symptoms. Unfortunately, ablation is largely ineffective in “persistent” AF (in patients experiencing symptoms lasting over a 7-day period) which makes up 50% of all patients. One of the primary reasons for ablation’s ineffectiveness is the procedure does not target the key underlying molecular mechanisms responsible for aberrant electrical remodeling and formation of fibrotic tissues.

Alternatively, Inomagen’s gene therapy targets the molecular mechanisms causing AF and has generated compelling proof-of-concept in large animal models. As a result, Inomagen’s gene therapy has the potential to supplant ablation, a $7 billion industry growing at 11.8% per year as the standard of care.

Inomagen Therapeutic: We thank our Board, management team, investors, and advisors for their incredible support of the company and shared vision to change the treatment paradigm for AF including the potential for superior efficacy and safety.

“Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R44HL154912. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

Medical Device News Magazine
Our publication is dedicated to bringing our readers the latest medical device news. We are proud to boast that our subscribers include medical specialists, device industry executives, investors, and other allied health professionals, as well as patients who are interested in researching various medical devices. We hope you find value in our easy-to-read publication and its overall purpose and objectives! Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

More News!

Lipogems® Announces 140 Independent Peer Reviewed Publications with 5 Years of Follow up in Orthopaedics

Giorgio Ninzoli, President of Lipogems International. "The gold standard for evidence is 1 year follow up and we are excited to report 5 years follow up with positive results after a single injection of MicroFat."

Study Outcomes Could Provide Insights Into New Targeted Treatments to Manage this Challenging Disease

The study aims to determine if immediate biological preservation of patient-derived chordoma tumor tissue, collected intraoperatively and implanted for serial sampling in translational research, will provide new insights into the biological weakness of the disease and contribute to developing improved treatment therapies reports NICO.

Study Validates Lunit AI as a Game-Changer, Poised to Replace One Human Reader in Breast Cancer Screening

Utilizing Lunit INSIGHT MMG, an FDA-cleared and CE-marked AI solution for mammography analysis, this research backs AI's potential to replace one human reader under Europe's double reading guideline and underscores its capacity to alleviate the strain on radiologists.

MedAlliance Announces Enrollment of over 1,660 Patients in Landmark SELUTION DeNovo Study

SELUTION DeNovo Study is the largest DEB study ever initiated, involving up to 70 participating sites across 15 countries. Patients are randomized before any vessel preparation to reflect current medical practice and to reduce bias.  The objectives of the study are to demonstrate non-inferiority at both one and five years, and superiority for target vessel failure (TVF) at five years.

Vitestro Starts Largest-scale Clinical Trial Globally for its Autonomous Blood Drawing Device, with Enrolment of First Patients in A.D.O.P.T.

Vitestro expects to obtain CE marking by the end of 2024. The first 350 patients have currently been enrolled the A.D.O.P.T. (Autonomous Optimization and Performance Tests for Blood Testing) Trial at study site Result Laboratorium in the Albert Schweitzer Hospital. Investigational partners, in addition to Result Laboratorium - Albert Schweitzer Hospital, are St. Antonius, OLVG Lab and Amsterdam UMC.

By using this website you agree to accept Medical Device News Magazine Privacy Policy