Tele: 561.316.3330
Breaking Medical Device News

Monday, October 18, 2021
HomeCLINICAL TRIALS, STUDIES, DATAIntraOp Medical Announces First Patients Enrolled in FLASH Clinical Trial

IntraOp Medical Announces First Patients Enrolled in FLASH Clinical Trial

IntraOp Medical Corporation announced today that Lausanne University Hospital (CHUV, Switzerland) enrolled the first patients in the Impulse Trial: A phase I dose-escalation study of high dose rate radiotherapy with electrons in patients with skin metastases from melanoma.

The trial is a key milestone for the groundbreaking research collaboration agreement between IntraOp and the CHUV, executed in 2020. The Impulse Trial is the first in the world to evaluate the potential of leveraging the biological phenomenon known as the “FLASH Effect” to provide radiotherapy with curative intent to radio-resistant cancers.

To conduct the study, researchers will utilize the IntraOp® Mobetron® platform modified to deliver precision electron beam therapy at high dose rates to produce the FLASH effect. “Leveraging their vast experience studying FLASH with an experimental LINAC, the CHUV’s researchers have diligently worked through the past year to prepare the FLASH capability of the Mobetron for biological and now human clinical work,” stated Kenneth Brooks, Ph.D. Vice President of Sales and Corporate Strategy at IntraOp. “With its fine beam structure control capabilities now validated, the Mobetron is the clear choice for researchers who, as those of the CHUV, are looking to explore possible effects of changing fine structure on the basic science that underlies this biologic effect and thus expands their institution’s research capabilities into FLASH with a clear path to clinical translation.”

Scientists and clinician-researchers from CHUV are world-renowned pioneers in the characterization of the FLASH effect, having published numerous groundbreaking studies in animal testing as well as the first human treatment. In preclinical studies, the FLASH effect has demonstrated several biological benefits and an improved therapeutic index by producing a protective effect for normal tissue at certain ultra-high dose rates and volumes. Professor Jean Bourhis, head of radiation oncology and principal investigator noted: “The Impulse Trial is the first in a series of clinical trials we have outlined to better understand the potential of the FLASH effect. Melanoma is one of the most radio-resistant cancers and curative therapy with conventional radiotherapy is rarely possible. By leveraging the FLASH effect, we may be able to optimize the therapeutic ratio and escalate the irradiation dose to completely kill cancer cells with a protective effect on normal tissue.”

“The Impulse trial is a major step forward for FLASH research and we congratulate Prof. Bourhis, Dr. Vozenin, Dr. Moeckli, and the rest of the team at CHUV in their ongoing achievements to realize this breakthrough,” said Derek T. DeScioli, Chief Executive Officer of IntraOp. “With our advanced electron therapy technology, commitment to patient-driven innovation, and growing cohort of research collaborators we are excited to be leading this new frontier in radiation oncology,” added Mr. DeScioli.

Note: IntraOp’s High Dose Rate (HDR) functionality is for investigational use only and is not approved for routine clinical use.

Medical Device News Magazinehttps://infomeddnews.com
Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

Stay Connected

spot_img

Don't Miss

Ganymed Robotics Awarded a €2.5M Grant from the EC through the EIC Accelerator Program

Ganymed Robotics is developing a radically new approach to surgical robotics by combining computer vision, a branch of artificial intelligence, and mechatronics.

Global Healthcare Exchange Announces Acquisition of Explorer Surgical

Explorer Surgical will operate as a wholly-owned subsidiary of GHX.

Arlington Scientific Broadens Product Portfolio and Further Expands its Product Offering Through the acquisition of Non-Mammalian Blocking Buffers

Arlington Scientific, Inc. (ASI) is pleased to announce that it has acquired the non-mammalian blocking buffer product line from Clark McDermith, former owner of...

Laborie Medical Technologies Acquires Pelvalon

Laborie was represented by Piper Sandler (financial advisor) and Simpson Thacher & Bartlett LLP (legal advisor). Pelvalon was represented by J.P. Morgan Securities LLC (financial advisor) and Dorsey & Whitney LLP (legal advisor).

Herculite Products, Inc. Promotes Two Employees to New Roles

Paul Flaherty Chief Strategy Officer and Marco Angelone is being promoted to the role of Chief Financial Officer.

Prof. Joseph Kvedar Added to the Sweetch Advisory Board Member

Prof. Josdeph Kvedar is the current chair of the board at the American Telemedicine Association (ATA), formerly VP of Connected Health at Mass-Gen Brigham, co-chair of the American Medical Association (AMA) Digital Medicine Payment Advisory Group, and author of The Internet of Healthy Things and The New Mobile Age.

Sid Bala Named President of HealthChampion

Sid Bala is the former president and chief executive officer of alligatortek, a custom software applications company that was acquired by HealthChampion in 2020 where he led them for 27 years after he founded the business

Cochlear Announces FDA Approval and Clearance of first-of-its-kind Remote Care Capabilities for Nucleus and Baha Systems

The FDA approval for the cochlear implant solution and FDA clearance for the Baha solution is the first step in commercializing the product offering, anticipated spring 2022, and complement Cochlear's existing Remote Care offerings.

By using this website you agree to accept Medical Device News Magazine Privacy Policy