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Tetrous, Inc., a Sherman Oaks-based company focused on biologic solutions for bone-to-tendon healing, announces expanded clinical use of its EnFix implants across multiple anatomical enthesis beyond rotator cuff repair.

New applications include proximal/distal biceps tenodesis, insertional Achilles tendinopathy, gluteus medius and proximal hamstring reattachment, lateral epicondyle repair, and subscapularis repair during total shoulder arthroplasty.

Driven by high failure rates in bone-to-tendon repair and increasing recognition of the enthesis as a critical biomechanical interface, these expanded indications are projected to increase the total addressable market (TAM) for EnFix to almost $2 Billion in the USA alone. EnFix TAC® and EnFix RC™ are currently in clinical use in the United States, Australia, and New Zealand, with global expansion underway.

Surgeons have adopted EnFix to address diverse enthesis injuries.

EnFix implants are composed of 100% demineralized bone fiber (DBF), providing osteoinductive and osteoconductive properties that initiate endochondral ossification—replicating the embryologic development of the enthesis. Preclinical data demonstrate Sharpey-like fiber formation and enhanced biomechanical strength at the bone-to-tendon interface, reinforcing the implant’s role in biologic enthesis reconstruction.

Tetrous continues to collect clinical data across a broad range of orthopedic procedures and will provide updates as evidence develops. The EnFix implant is engineered to integrate seamlessly into existing techniques, offering biologic reinforcement with minimal surgical disruption.

This milestone underscores Tetrous‘ commitment to addressing Enthesis Failure Syndrome and advancing biologic healing in sports medicine and orthopedic surgery.