Vascular Surgeon in Ireland Views: The COVID-19 Cytokine Storm & the Novel Truth

Based on observations in the USA, Spain, Italy, France, and the UK, and from postmortem of lung involvement in COVID 19, all revealed pulmonary thrombosis, which is not typical ARDS. More alarming, was that patient hypoxemia was not responding to PEEP but high oxygen flow[1].

A Chinese scientist[2]  described the hypothesis of COVID 19, as methemoglobin, where COVID 19 virus structural protein, sticks to heme – displaces oxygen – which alters the iron-free ion, that leads to inflammation of alveolar macrophages which culminate to the systemic response ending in a cytokine storm. They suggested that free radical’s scavengers and iron-chelating agents if are added to the protocol of management might ameliorate the inflammatory response.

COVID 19, SARS2 is not ‘pneumonia’ nor ARDS. Invasive ventilation is the last resort, as emergency intubation from the Chinese, Italian and American experience had higher mortality, not to mention complications from tracheal scarring and stiff lung during the duration of intubation.  Furthermore, a new treatment protocol needs to be established in order to control the prolonged and progressive hypoxia of COVID191.

People are desaturating due to the failure of the blood to carry oxygen. This will lead to multi-organ failure and high mortality. The lung damage seen on CT scans is due to the oxidative stress released from the hemolysis red blood cells, which in turn overwhelm the natural defenses against pulmonary oxidative stress and cause Cytokine storm. There is always-bilateral ground-glass opacity in the lungs. Recurrent admission for post-hypoxic leukoencephalopathy fortifies the findings of the Italians, Spanish, and Americans3 that COVID-19 patients are suffering from metabolic hypoxia due to blood capacity failure.

The Chinese hypothesis2 that had been publicized that the following cascade might explain the vicious circle theoretically that the patient goes through

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once the hemoglobin is impaired, the red blood cell is essentially none functioning in carrying and delivering oxygen to any tissues. This leads to the destruction of the red blood cells and the patient’s oxygen saturation levels drop significantly.

COVID 19 patients, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry oxygen where the body compensates by secreting excess erythropoietin to stimulate the bone marrow to secrete new red blood cells.



[1] COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism Wenzhong Liu 1,2,*, Hualan Li2


Please feel free to comment on this opinion.  The comment field can be found at the bottom of the page. 


Medical Device News Magazine
Medical Device News Magazine provides our readership with breaking medical device / biotechnology news. Our subscribers include medical specialists, device industry executives, investors, and other allied health professionals, as well as patients who are interested in researching various medical devices. We hope you find value in our easy-to-read publication and its overall objectives! Medical Device News Magazine is a division of PTM Healthcare Marketing, Inc. Pauline T. Mayer is the managing editor.

Experts Views and Opinions

Moby Cutter™ is one of the safest surgical wire cutters on the market today! Their medical design team has over 35 years of experience performing surgical procedures in Hospitals, Emergency Rooms and Urgent Care Systems. It has been cleared for commercialization per FDA guidelines and sold as a prescription only (Rx) medical device. Dr. Stanley shares the advantages of the Moby Cutter.
Health systems continue to face ongoing pressures to reduce costs while maintaining quality patient care. With the average operating margin for hospitals at 0.84%, health systems are searching for ways to more effectively manage operating and capital budgets. However, gaps in data often hinder health systems by hiding cost burdens throughout the organization. These hidden costs limit health systems to finding one-time-savings without lasting relief from industry-wide pressures.
Healthcare organizations face many challenges: they must protect patient privacy, deliver quality care, and meet strict regulations. These organizations, which include medical device manufacturers, are trusted to safeguard incredibly sensitive information, a task that carries immense responsibility. Read on to learn what this industry expert has to say.
Dr. Amy Hester writes, "However, while technology has brought about incredible advancements, an essential aspect must not be overlooked—integrating a human touch in healthcare delivery, particularly in the context of falls prevention among veterans." Read to learn more.
Dr. Kashani offers insights for couples trying to conceive during the holidays, from nutrition and stress management to products to consider.

By using this website you agree to accept Medical Device News Magazine Privacy Policy